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- NCIT_C66499 IAO_0000115 "The pamoate salt of pyrvinium, a quinoline-derived cyanine dye and an mitochondrial oxidative phosphorylation (OxPhos) inhibitor, with anthelmintic and potential antineoplastic activities. Upon administration, pyrvinium pamoate may inhibit mitochondrial OxPhos and mitochondrial respiration, decreases mitochondrial function, prevents tumor cell metabolism and deprives tumor cells of energy, thereby preventing tumor cell proliferation and leading to tumor cell death in some types of cancer cells. Mitochondrial OxPhos is overactivated in cancer cells and plays a key role in tumor cell proliferation. Drug resistant tumor cells are very susceptible to decreased mitochondrial OxPhos as they cannot easily compensate for the decrease in mitochondrial function by increasing glycolysis." @default.
- NCIT_C66499 NCIT_NHC0 "C66499" @default.
- NCIT_C66499 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66499 NCIT_P107 "Pyrvinium Pamoate" @default.
- NCIT_C66499 NCIT_P108 "Pyrvinium Pamoate" @default.
- NCIT_C66499 NCIT_P207 "C0139597" @default.
- NCIT_C66499 NCIT_P210 "3546-41-6" @default.
- NCIT_C66499 NCIT_P319 "310X6S84LW" @default.
- NCIT_C66499 NCIT_P322 "CTRP" @default.
- NCIT_C66499 NCIT_P322 "FDA" @default.
- NCIT_C66499 NCIT_P329 "800895" @default.
- NCIT_C66499 NCIT_P330 "800895" @default.
- NCIT_C66499 NCIT_P350 "2C26H28N3.C23H14O6" @default.
- NCIT_C66499 NCIT_P366 "Pyrvinium_Pamoate" @default.
- NCIT_C66499 NCIT_P399 "800895" @default.
- NCIT_C66499 normalizedInformationContent "100" @default.
- NCIT_C66499 referenceCount "1" @default.
- NCIT_C66499 hasExactSynonym "6-(Dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-methylquinolinium 4,4'-methylenebis(3-hydroxy-2-naphthoate) (2:1)" @default.
- NCIT_C66499 hasExactSynonym "PYRVINIUM PAMOATE" @default.
- NCIT_C66499 hasExactSynonym "Pyrvinium Pamoate" @default.
- NCIT_C66499 hasExactSynonym "Quinolinium, 6-(Dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl)-1-methyl-, Salt with 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid) (2:1)" @default.
- NCIT_C66499 inSubset NCIT_C116977 @default.
- NCIT_C66499 inSubset NCIT_C116978 @default.
- NCIT_C66499 inSubset NCIT_C176424 @default.
- NCIT_C66499 inSubset NCIT_C63923 @default.
- NCIT_C66499 type Class @default.
- NCIT_C66499 isDefinedBy ncit.owl @default.
- NCIT_C66499 label "Pyrvinium Pamoate" @default.
- NCIT_C66499 subClassOf NCIT_C1908 @default.
- NCIT_C66499 subClassOf NCIT_C1909 @default.
- NCIT_C66499 subClassOf NCIT_C250 @default.
- NCIT_C66499 subClassOf NCIT_C254 @default.
- NCIT_C66499 subClassOf NCIT_C276 @default.
- NCIT_C66499 subClassOf NCIT_C66499 @default.