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- NCIT_C665 IAO_0000115 "The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin." @default.
- NCIT_C665 NCIT_A32 NCIT_C1909 @default.
- NCIT_C665 NCIT_A6 NCIT_C62050 @default.
- NCIT_C665 NCIT_A7 NCIT_C18434 @default.
- NCIT_C665 NCIT_NHC0 "C665" @default.
- NCIT_C665 NCIT_P106 "Antibiotic" @default.
- NCIT_C665 NCIT_P106 "Organic Chemical" @default.
- NCIT_C665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C665 NCIT_P107 "Mitoxantrone Hydrochloride" @default.
- NCIT_C665 NCIT_P108 "Mitoxantrone Hydrochloride" @default.
- NCIT_C665 NCIT_P175 "301739" @default.
- NCIT_C665 NCIT_P207 "C0700458" @default.
- NCIT_C665 NCIT_P210 "70476-82-3" @default.
- NCIT_C665 NCIT_P302 "Acute Leukemia; Breast cancer; Non Hodgkins Lymphoma; Multiple sclerosis; Prostate cancer" @default.
- NCIT_C665 NCIT_P319 "U6USW86RD0" @default.
- NCIT_C665 NCIT_P322 "CTRP" @default.
- NCIT_C665 NCIT_P322 "FDA" @default.
- NCIT_C665 NCIT_P322 "GDC" @default.
- NCIT_C665 NCIT_P325 "A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics." @default.
- NCIT_C665 NCIT_P329 "39219" @default.
- NCIT_C665 NCIT_P330 "39219" @default.
- NCIT_C665 NCIT_P350 "C22H28N4O6.2HCl" @default.
- NCIT_C665 NCIT_P366 "Mitoxantrone" @default.
- NCIT_C665 NCIT_P368 "CHEBI:50727" @default.
- NCIT_C665 NCIT_P375 "Mitoxantrone Hydrochloride" @default.
- NCIT_C665 NCIT_P399 "39219" @default.
- NCIT_C665 normalizedInformationContent "69.331246848109103" @default.
- NCIT_C665 referenceCount "103" @default.
- NCIT_C665 hasExactSynonym "1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride" @default.
- NCIT_C665 hasExactSynonym "1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone Dihydrochloride" @default.
- NCIT_C665 hasExactSynonym "CL 232315" @default.
- NCIT_C665 hasExactSynonym "DHAD" @default.
- NCIT_C665 hasExactSynonym "DHAQ" @default.
- NCIT_C665 hasExactSynonym "Dihydroxyanthracenedione Dihydrochloride" @default.
- NCIT_C665 hasExactSynonym "MITOXANTRONE HYDROCHLORIDE" @default.
- NCIT_C665 hasExactSynonym "Mitoxantrone Dihydrochloride" @default.
- NCIT_C665 hasExactSynonym "Mitoxantrone Hydrochloride" @default.
- NCIT_C665 hasExactSynonym "Mitoxantroni Hydrochloridum" @default.
- NCIT_C665 hasExactSynonym "Mitozantrone Hydrochloride" @default.
- NCIT_C665 hasExactSynonym "Mitroxone" @default.
- NCIT_C665 hasExactSynonym "Neotalem" @default.
- NCIT_C665 hasExactSynonym "Novantrone" @default.
- NCIT_C665 hasExactSynonym "Onkotrone" @default.
- NCIT_C665 hasExactSynonym "Pralifan" @default.
- NCIT_C665 inSubset NCIT_C116977 @default.
- NCIT_C665 inSubset NCIT_C116978 @default.
- NCIT_C665 inSubset NCIT_C128784 @default.
- NCIT_C665 inSubset NCIT_C157711 @default.
- NCIT_C665 inSubset NCIT_C157712 @default.
- NCIT_C665 inSubset NCIT_C176424 @default.
- NCIT_C665 inSubset NCIT_C177537 @default.
- NCIT_C665 inSubset NCIT_C63923 @default.
- NCIT_C665 type Class @default.
- NCIT_C665 isDefinedBy ncit.owl @default.
- NCIT_C665 label "Mitoxantrone Hydrochloride" @default.
- NCIT_C665 subClassOf NCIT_C129824 @default.
- NCIT_C665 subClassOf NCIT_C129825 @default.
- NCIT_C665 subClassOf NCIT_C1748 @default.
- NCIT_C665 subClassOf NCIT_C186664 @default.
- NCIT_C665 subClassOf NCIT_C1908 @default.
- NCIT_C665 subClassOf NCIT_C1909 @default.
- NCIT_C665 subClassOf NCIT_C1913 @default.
- NCIT_C665 subClassOf NCIT_C1915 @default.
- NCIT_C665 subClassOf NCIT_C1933 @default.
- NCIT_C665 subClassOf NCIT_C1968 @default.
- NCIT_C665 subClassOf NCIT_C200714 @default.
- NCIT_C665 subClassOf NCIT_C2189 @default.
- NCIT_C665 subClassOf NCIT_C253 @default.
- NCIT_C665 subClassOf NCIT_C274 @default.
- NCIT_C665 subClassOf NCIT_C2842 @default.
- NCIT_C665 subClassOf NCIT_C471 @default.
- NCIT_C665 subClassOf NCIT_C552 @default.
- NCIT_C665 subClassOf NCIT_C553 @default.
- NCIT_C665 subClassOf NCIT_C582 @default.
- NCIT_C665 subClassOf NCIT_C665 @default.
- NCIT_C665 subClassOf NCIT_C718 @default.
- NCIT_C665 subClassOf NCIT_C796 @default.
- NCIT_C665 subClassOf NCIT_C94716 @default.