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- NCIT_C66507 IAO_0000115 "An orally available, piperazine derivative with anti-anginal and potential antineoplastic activities. Ranolazine's mechanism of action for its anti-ischemic effects has yet to be fully elucidated but may involve the alteration of the trans-cellular late sodium current in the ischemic myocyte. By preventing the rise of intracellular sodium levels, ranolazine may affect the transport activity of sodium-dependent calcium channels and prevent the calcium overload during myocardial ischemia, thereby preventing cellular injury. Ranolazine's potential antineoplastic effect may depend on its inhibitory effect on fatty acid oxidation, which may sensitize tumor cells to apoptosis and decrease tumor cell proliferation; fatty acid oxidation provides energy and promotes tumor cell proliferation and survival." @default.
- NCIT_C66507 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66507 NCIT_A5 NCIT_C66508 @default.
- NCIT_C66507 NCIT_NHC0 "C66507" @default.
- NCIT_C66507 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66507 NCIT_P107 "Ranolazine" @default.
- NCIT_C66507 NCIT_P108 "Ranolazine" @default.
- NCIT_C66507 NCIT_P207 "C0073633" @default.
- NCIT_C66507 NCIT_P210 "95635-55-5" @default.
- NCIT_C66507 NCIT_P319 "A6IEZ5M406" @default.
- NCIT_C66507 NCIT_P322 "CTRP" @default.
- NCIT_C66507 NCIT_P322 "FDA" @default.
- NCIT_C66507 NCIT_P322 "GDC" @default.
- NCIT_C66507 NCIT_P329 "753754" @default.
- NCIT_C66507 NCIT_P330 "753754" @default.
- NCIT_C66507 NCIT_P350 "C24H33N3O4" @default.
- NCIT_C66507 NCIT_P366 "Ranolazine" @default.
- NCIT_C66507 NCIT_P375 "Ranolazine" @default.
- NCIT_C66507 NCIT_P399 "753754" @default.
- NCIT_C66507 normalizedInformationContent "100" @default.
- NCIT_C66507 referenceCount "1" @default.
- NCIT_C66507 hasExactSynonym "1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-(2-hydroxy- 3-(2-methoxyphenoxy)propyl)-" @default.
- NCIT_C66507 hasExactSynonym "RANOLAZINE" @default.
- NCIT_C66507 hasExactSynonym "Ranexa" @default.
- NCIT_C66507 hasExactSynonym "Ranolazine" @default.
- NCIT_C66507 inSubset NCIT_C116977 @default.
- NCIT_C66507 inSubset NCIT_C116978 @default.
- NCIT_C66507 inSubset NCIT_C128784 @default.
- NCIT_C66507 inSubset NCIT_C157711 @default.
- NCIT_C66507 inSubset NCIT_C157712 @default.
- NCIT_C66507 inSubset NCIT_C176424 @default.
- NCIT_C66507 inSubset NCIT_C177537 @default.
- NCIT_C66507 inSubset NCIT_C63923 @default.
- NCIT_C66507 type Class @default.
- NCIT_C66507 isDefinedBy ncit.owl @default.
- NCIT_C66507 label "Ranolazine" @default.
- NCIT_C66507 subClassOf NCIT_C1908 @default.
- NCIT_C66507 subClassOf NCIT_C1909 @default.
- NCIT_C66507 subClassOf NCIT_C66507 @default.
- NCIT_C66507 subClassOf NCIT_C78274 @default.
- NCIT_C66507 subClassOf NCIT_C78322 @default.
- NCIT_C66507 subClassOf NCIT_C93038 @default.