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- NCIT_C66560 IAO_0000115 "A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spiraprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C66560 NCIT_A5 NCIT_C66561 @default.
- NCIT_C66560 NCIT_NHC0 "C66560" @default.
- NCIT_C66560 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66560 NCIT_P108 "Spirapril" @default.
- NCIT_C66560 NCIT_P207 "C0075007" @default.
- NCIT_C66560 NCIT_P210 "83647-97-6" @default.
- NCIT_C66560 NCIT_P319 "96U2K78I3V" @default.
- NCIT_C66560 NCIT_P322 "FDA" @default.
- NCIT_C66560 NCIT_P350 "C22H30N2O5S2" @default.
- NCIT_C66560 NCIT_P366 "Spirapril" @default.
- NCIT_C66560 normalizedInformationContent "100" @default.
- NCIT_C66560 referenceCount "1" @default.
- NCIT_C66560 hasExactSynonym "SPIRAPRIL" @default.
- NCIT_C66560 hasExactSynonym "Spirapril" @default.
- NCIT_C66560 inSubset NCIT_C63923 @default.
- NCIT_C66560 type Class @default.
- NCIT_C66560 isDefinedBy ncit.owl @default.
- NCIT_C66560 label "Spirapril" @default.
- NCIT_C66560 subClassOf NCIT_C1908 @default.
- NCIT_C66560 subClassOf NCIT_C1909 @default.
- NCIT_C66560 subClassOf NCIT_C247 @default.
- NCIT_C66560 subClassOf NCIT_C270 @default.
- NCIT_C66560 subClassOf NCIT_C471 @default.
- NCIT_C66560 subClassOf NCIT_C66560 @default.
- NCIT_C66560 subClassOf NCIT_C78274 @default.
- NCIT_C66560 subClassOf NCIT_C783 @default.