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- NCIT_C66567 IAO_0000115 "A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis." @default.
- NCIT_C66567 NCIT_A6 NCIT_C29468 @default.
- NCIT_C66567 NCIT_NHC0 "C66567" @default.
- NCIT_C66567 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66567 NCIT_P108 "Silver Sulfadiazine" @default.
- NCIT_C66567 NCIT_P207 "C0037134" @default.
- NCIT_C66567 NCIT_P210 "22199-08-2" @default.
- NCIT_C66567 NCIT_P319 "W46JY43EJR" @default.
- NCIT_C66567 NCIT_P322 "FDA" @default.
- NCIT_C66567 NCIT_P329 "717602" @default.
- NCIT_C66567 NCIT_P330 "717602" @default.
- NCIT_C66567 NCIT_P350 "C10H9N4O2S.Ag" @default.
- NCIT_C66567 NCIT_P366 "Sulfadiazine_Silver" @default.
- NCIT_C66567 NCIT_P368 "CHEBI:9142" @default.
- NCIT_C66567 NCIT_P399 "717602" @default.
- NCIT_C66567 normalizedInformationContent "100" @default.
- NCIT_C66567 referenceCount "1" @default.
- NCIT_C66567 hasExactSynonym "Flamazine" @default.
- NCIT_C66567 hasExactSynonym "SILVER SULFADIAZINE" @default.
- NCIT_C66567 hasExactSynonym "SSD" @default.
- NCIT_C66567 hasExactSynonym "Silvadene" @default.
- NCIT_C66567 hasExactSynonym "Silver Sulfadiazine" @default.
- NCIT_C66567 hasExactSynonym "Sliverex" @default.
- NCIT_C66567 hasExactSynonym "Sulfadiazine Silver" @default.
- NCIT_C66567 hasExactSynonym "Thermazene" @default.
- NCIT_C66567 inSubset NCIT_C176424 @default.
- NCIT_C66567 inSubset NCIT_C63923 @default.
- NCIT_C66567 type Class @default.
- NCIT_C66567 isDefinedBy ncit.owl @default.
- NCIT_C66567 label "Silver Sulfadiazine" @default.
- NCIT_C66567 subClassOf NCIT_C1908 @default.
- NCIT_C66567 subClassOf NCIT_C1909 @default.
- NCIT_C66567 subClassOf NCIT_C254 @default.
- NCIT_C66567 subClassOf NCIT_C28394 @default.
- NCIT_C66567 subClassOf NCIT_C29739 @default.
- NCIT_C66567 subClassOf NCIT_C66567 @default.