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- NCIT_C66721 IAO_0000115 "A levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity." @default.
- NCIT_C66721 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66721 NCIT_A6 NCIT_C1559 @default.
- NCIT_C66721 NCIT_NHC0 "C66721" @default.
- NCIT_C66721 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66721 NCIT_P108 "Levoleucovorin Calcium" @default.
- NCIT_C66721 NCIT_P207 "C1881372" @default.
- NCIT_C66721 NCIT_P210 "80433-71-2" @default.
- NCIT_C66721 NCIT_P302 "Colorectal Cancer" @default.
- NCIT_C66721 NCIT_P319 "778XL6VBS8" @default.
- NCIT_C66721 NCIT_P322 "FDA" @default.
- NCIT_C66721 NCIT_P322 "GDC" @default.
- NCIT_C66721 NCIT_P325 "A drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Calcium levoleucovorin is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Calcium levoleucovorin is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent." @default.
- NCIT_C66721 NCIT_P329 "748638" @default.
- NCIT_C66721 NCIT_P330 "748638" @default.
- NCIT_C66721 NCIT_P350 "C20H21N7O7.Ca" @default.
- NCIT_C66721 NCIT_P366 "Levoleucovorin_Calcium" @default.
- NCIT_C66721 NCIT_P375 "Levoleucovorin Calcium" @default.
- NCIT_C66721 NCIT_P399 "748638" @default.
- NCIT_C66721 normalizedInformationContent "100" @default.
- NCIT_C66721 referenceCount "1" @default.
- NCIT_C66721 hasExactSynonym "Fusilev" @default.
- NCIT_C66721 hasExactSynonym "LEVOLEUCOVORIN CALCIUM" @default.
- NCIT_C66721 hasExactSynonym "Levoleucovorin Calcium" @default.
- NCIT_C66721 hasExactSynonym "calcium levoleucovorin" @default.
- NCIT_C66721 inSubset NCIT_C157711 @default.
- NCIT_C66721 inSubset NCIT_C157712 @default.
- NCIT_C66721 inSubset NCIT_C176424 @default.
- NCIT_C66721 inSubset NCIT_C177537 @default.
- NCIT_C66721 inSubset NCIT_C63923 @default.
- NCIT_C66721 type Class @default.
- NCIT_C66721 isDefinedBy ncit.owl @default.
- NCIT_C66721 label "Levoleucovorin Calcium" @default.
- NCIT_C66721 subClassOf NCIT_C1908 @default.
- NCIT_C66721 subClassOf NCIT_C1909 @default.
- NCIT_C66721 subClassOf NCIT_C2078 @default.
- NCIT_C66721 subClassOf NCIT_C2140 @default.
- NCIT_C66721 subClassOf NCIT_C66721 @default.