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- NCIT_C66868 IAO_0000115 "A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS)." @default.
- NCIT_C66868 NCIT_A5 NCIT_C355 @default.
- NCIT_C66868 NCIT_A5 NCIT_C98229 @default.
- NCIT_C66868 NCIT_NHC0 "C66868" @default.
- NCIT_C66868 NCIT_P106 "Antibiotic" @default.
- NCIT_C66868 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66868 NCIT_P108 "Ceftazidime" @default.
- NCIT_C66868 NCIT_P207 "C0007559" @default.
- NCIT_C66868 NCIT_P210 "78439-06-2" @default.
- NCIT_C66868 NCIT_P319 "9M416Z9QNR" @default.
- NCIT_C66868 NCIT_P322 "FDA" @default.
- NCIT_C66868 NCIT_P350 "C22H21N6O7S2."H".5H2O" @default.
- NCIT_C66868 NCIT_P366 "Ceftazidime_Base" @default.
- NCIT_C66868 NCIT_P368 "CHEBI:3509" @default.
- NCIT_C66868 normalizedInformationContent "100" @default.
- NCIT_C66868 referenceCount "1" @default.
- NCIT_C66868 hasExactSynonym "CEFTAZIDIME" @default.
- NCIT_C66868 hasExactSynonym "Ceftazidime Pentahydrate" @default.
- NCIT_C66868 hasExactSynonym "Ceftazidime" @default.
- NCIT_C66868 hasExactSynonym "Ceptaz" @default.
- NCIT_C66868 hasExactSynonym "Fortaz" @default.
- NCIT_C66868 hasExactSynonym "GR 20263" @default.
- NCIT_C66868 hasExactSynonym "LY 139381" @default.
- NCIT_C66868 hasExactSynonym "Pentacef" @default.
- NCIT_C66868 hasExactSynonym "Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Hydroxide, Inner Salt, Pentahydrate, (6R-(6alpha,7beta(Z)))-" @default.
- NCIT_C66868 inSubset NCIT_C63923 @default.
- NCIT_C66868 type Class @default.
- NCIT_C66868 isDefinedBy ncit.owl @default.
- NCIT_C66868 label "Ceftazidime" @default.
- NCIT_C66868 subClassOf NCIT_C1908 @default.
- NCIT_C66868 subClassOf NCIT_C1909 @default.
- NCIT_C66868 subClassOf NCIT_C254 @default.
- NCIT_C66868 subClassOf NCIT_C258 @default.
- NCIT_C66868 subClassOf NCIT_C260 @default.
- NCIT_C66868 subClassOf NCIT_C357 @default.
- NCIT_C66868 subClassOf NCIT_C66868 @default.