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- NCIT_C66869 IAO_0000115 "A non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle." @default.
- NCIT_C66869 NCIT_A5 NCIT_C29165 @default.
- NCIT_C66869 NCIT_A7 NCIT_C179874 @default.
- NCIT_C66869 NCIT_NHC0 "C66869" @default.
- NCIT_C66869 NCIT_P106 "Organic Chemical" @default.
- NCIT_C66869 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66869 NCIT_P107 "Losartan" @default.
- NCIT_C66869 NCIT_P108 "Losartan" @default.
- NCIT_C66869 NCIT_P207 "C0126174" @default.
- NCIT_C66869 NCIT_P210 "114798-26-4" @default.
- NCIT_C66869 NCIT_P319 "JMS50MPO89" @default.
- NCIT_C66869 NCIT_P322 "CTRP" @default.
- NCIT_C66869 NCIT_P322 "FDA" @default.
- NCIT_C66869 NCIT_P325 "A drug used to treat high blood pressure. Losartan blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist." @default.
- NCIT_C66869 NCIT_P350 "C22H23ClN6O" @default.
- NCIT_C66869 NCIT_P366 "Losartan" @default.
- NCIT_C66869 NCIT_P368 "CHEBI:6541" @default.
- NCIT_C66869 normalizedInformationContent "100" @default.
- NCIT_C66869 referenceCount "1" @default.
- NCIT_C66869 hasExactSynonym "2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol" @default.
- NCIT_C66869 hasExactSynonym "LOSARTAN" @default.
- NCIT_C66869 hasExactSynonym "Losartan" @default.
- NCIT_C66869 hasExactSynonym "losartan" @default.
- NCIT_C66869 inSubset NCIT_C116977 @default.
- NCIT_C66869 inSubset NCIT_C116978 @default.
- NCIT_C66869 inSubset NCIT_C173381 @default.
- NCIT_C66869 inSubset NCIT_C173383 @default.
- NCIT_C66869 inSubset NCIT_C63923 @default.
- NCIT_C66869 type Class @default.
- NCIT_C66869 isDefinedBy ncit.owl @default.
- NCIT_C66869 label "Losartan" @default.
- NCIT_C66869 subClassOf NCIT_C1908 @default.
- NCIT_C66869 subClassOf NCIT_C1909 @default.
- NCIT_C66869 subClassOf NCIT_C270 @default.
- NCIT_C66869 subClassOf NCIT_C66869 @default.
- NCIT_C66869 subClassOf NCIT_C66930 @default.
- NCIT_C66869 subClassOf NCIT_C78274 @default.