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- NCIT_C66935 IAO_0000115 "A second-generation antisense oligonucleotide against survivin mRNA with potential antitumor activity. Gataparsen hybridizes to survivin mRNA, thereby blocking translation of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin, expressed during embryonal development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Silencing expression of survivin potentially leads to restoration of the apoptotic process in cancer cells, thereby facilitating chemotherapeutic treatments." @default.
- NCIT_C66935 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66935 NCIT_A7 NCIT_C18179 @default.
- NCIT_C66935 NCIT_NHC0 "C66935" @default.
- NCIT_C66935 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C66935 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66935 NCIT_P107 "Gataparsen Sodium" @default.
- NCIT_C66935 NCIT_P108 "Gataparsen Sodium" @default.
- NCIT_C66935 NCIT_P207 "C1832051" @default.
- NCIT_C66935 NCIT_P210 "928768-71-2" @default.
- NCIT_C66935 NCIT_P319 "3KY0EUQ36S" @default.
- NCIT_C66935 NCIT_P322 "CTRP" @default.
- NCIT_C66935 NCIT_P322 "FDA" @default.
- NCIT_C66935 NCIT_P322 "GDC" @default.
- NCIT_C66935 NCIT_P329 "532253" @default.
- NCIT_C66935 NCIT_P330 "532253" @default.
- NCIT_C66935 NCIT_P366 "LY2181308" @default.
- NCIT_C66935 NCIT_P375 "Gataparsen Sodium" @default.
- NCIT_C66935 NCIT_P399 "532253" @default.
- NCIT_C66935 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C66935 NCIT_R146 NCIT_C17021 @default.
- NCIT_C66935 NCIT_R146 NCIT_C18179 @default.
- NCIT_C66935 NCIT_R146 NCIT_C18466 @default.
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- NCIT_C66935 NCIT_R146 NCIT_C20027 @default.
- NCIT_C66935 NCIT_R146 NCIT_C26548 @default.
- NCIT_C66935 normalizedInformationContent "100" @default.
- NCIT_C66935 referenceCount "1" @default.
- NCIT_C66935 hasExactSynonym "Antisurvivin Antisense Oligonucleotide LY2181308" @default.
- NCIT_C66935 hasExactSynonym "GATAPARSEN SODIUM" @default.
- NCIT_C66935 hasExactSynonym "Gataparsen Sodium" @default.
- NCIT_C66935 hasExactSynonym "LY 2181308" @default.
- NCIT_C66935 hasExactSynonym "LY-2181308" @default.
- NCIT_C66935 hasExactSynonym "LY2181308 Heptadecasodium Salt" @default.
- NCIT_C66935 hasExactSynonym "LY2181308" @default.
- NCIT_C66935 inSubset NCIT_C116977 @default.
- NCIT_C66935 inSubset NCIT_C116978 @default.
- NCIT_C66935 inSubset NCIT_C128784 @default.
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- NCIT_C66935 inSubset NCIT_C176424 @default.
- NCIT_C66935 inSubset NCIT_C177537 @default.
- NCIT_C66935 inSubset NCIT_C63923 @default.
- NCIT_C66935 type Class @default.
- NCIT_C66935 isDefinedBy ncit.owl @default.
- NCIT_C66935 label "Gataparsen Sodium" @default.
- NCIT_C66935 subClassOf B0726a0e48b98282699b8dc4f725d15f2 @default.
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- NCIT_C66935 subClassOf NCIT_C1962 @default.
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- NCIT_C66935 subClassOf NCIT_C66935 @default.