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- NCIT_C66945 IAO_0000115 "The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition." @default.
- NCIT_C66945 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66945 NCIT_A6 NCIT_C1333 @default.
- NCIT_C66945 NCIT_NHC0 "C66945" @default.
- NCIT_C66945 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66945 NCIT_P107 "Dexrazoxane Hydrochloride" @default.
- NCIT_C66945 NCIT_P108 "Dexrazoxane Hydrochloride" @default.
- NCIT_C66945 NCIT_P207 "C0982118" @default.
- NCIT_C66945 NCIT_P210 "149003-01-0" @default.
- NCIT_C66945 NCIT_P302 "severe side effects caused by certain types of chemotherapy including extravasation, cardiac side effects by doxorubicin." @default.
- NCIT_C66945 NCIT_P319 "5346058Q7S" @default.
- NCIT_C66945 NCIT_P322 "CTRP" @default.
- NCIT_C66945 NCIT_P322 "FDA" @default.
- NCIT_C66945 NCIT_P322 "GDC" @default.
- NCIT_C66945 NCIT_P325 "A drug used to treat severe side effects caused by certain anticancer drugs. It is used under the brand name Totect to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. It is also used under the brand name Zinecard to reduce heart damage in women given doxorubicin for breast cancer that has spread. Dexrazoxane hydrochloride is also being studied in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor." @default.
- NCIT_C66945 NCIT_P329 "39485" @default.
- NCIT_C66945 NCIT_P330 "39485" @default.
- NCIT_C66945 NCIT_P350 "C11H16N4O4.HCl" @default.
- NCIT_C66945 NCIT_P366 "Dexrazoxane_Hydrochloride" @default.
- NCIT_C66945 NCIT_P368 "CHEBI:50224" @default.
- NCIT_C66945 NCIT_P375 "Dexrazoxane Hydrochloride" @default.
- NCIT_C66945 NCIT_P399 "39485" @default.
- NCIT_C66945 NCIT_R124 NCIT_C17710 @default.
- NCIT_C66945 NCIT_R124 NCIT_C17828 @default.
- NCIT_C66945 NCIT_R124 NCIT_C18219 @default.
- NCIT_C66945 NCIT_R124 NCIT_C19426 @default.
- NCIT_C66945 NCIT_R124 NCIT_C19986 @default.
- NCIT_C66945 NCIT_R124 NCIT_C40483 @default.
- NCIT_C66945 NCIT_R124 NCIT_C40516 @default.
- NCIT_C66945 NCIT_R125 NCIT_C17710 @default.
- NCIT_C66945 NCIT_R125 NCIT_C17828 @default.
- NCIT_C66945 NCIT_R125 NCIT_C19536 @default.
- NCIT_C66945 NCIT_R125 NCIT_C28498 @default.
- NCIT_C66945 NCIT_R125 NCIT_C40576 @default.
- NCIT_C66945 NCIT_R125 NCIT_C40577 @default.
- NCIT_C66945 NCIT_R125 NCIT_C41583 @default.
- NCIT_C66945 NCIT_R125 NCIT_C41584 @default.
- NCIT_C66945 normalizedInformationContent "100" @default.
- NCIT_C66945 referenceCount "1" @default.
- NCIT_C66945 hasExactSynonym "Cardioxane" @default.
- NCIT_C66945 hasExactSynonym "DEXRAZOXANE HYDROCHLORIDE" @default.
- NCIT_C66945 hasExactSynonym "Dexrazoxane Hydrochloride" @default.
- NCIT_C66945 hasExactSynonym "Totect" @default.
- NCIT_C66945 hasExactSynonym "Zinecard" @default.
- NCIT_C66945 hasExactSynonym "dexrazoxane hydrochloride" @default.
- NCIT_C66945 inSubset NCIT_C116977 @default.
- NCIT_C66945 inSubset NCIT_C116978 @default.
- NCIT_C66945 inSubset NCIT_C128784 @default.
- NCIT_C66945 inSubset NCIT_C157711 @default.
- NCIT_C66945 inSubset NCIT_C157712 @default.
- NCIT_C66945 inSubset NCIT_C176424 @default.
- NCIT_C66945 inSubset NCIT_C177537 @default.
- NCIT_C66945 inSubset NCIT_C63923 @default.
- NCIT_C66945 type Class @default.
- NCIT_C66945 isDefinedBy ncit.owl @default.
- NCIT_C66945 label "Dexrazoxane Hydrochloride" @default.
- NCIT_C66945 subClassOf B02dbe9e36282d5e86d6e1d7ebd6ebad7 @default.
- NCIT_C66945 subClassOf B56d59167b22d035ae2db4286dac0b365 @default.
- NCIT_C66945 subClassOf B7c92f240c76a07cf87ceed1071f09e0f @default.
- NCIT_C66945 subClassOf Ba2e14a6a194add1e59ff65cf86b2c12d @default.
- NCIT_C66945 subClassOf Baec62e9806380d99b8320bed6e4c63a8 @default.
- NCIT_C66945 subClassOf Bc9ebc465f3ed308f46124fe0b20e7c03 @default.
- NCIT_C66945 subClassOf NCIT_C1908 @default.
- NCIT_C66945 subClassOf NCIT_C1932 @default.
- NCIT_C66945 subClassOf NCIT_C360 @default.
- NCIT_C66945 subClassOf NCIT_C66945 @default.