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- NCIT_C66947 IAO_0000115 "A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs." @default.
- NCIT_C66947 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66947 NCIT_A7 NCIT_C30006 @default.
- NCIT_C66947 NCIT_NHC0 "C66947" @default.
- NCIT_C66947 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66947 NCIT_P107 "Multikinase Inhibitor AT9283" @default.
- NCIT_C66947 NCIT_P108 "Multikinase Inhibitor AT9283" @default.
- NCIT_C66947 NCIT_P207 "C1879521" @default.
- NCIT_C66947 NCIT_P210 "896466-04-9" @default.
- NCIT_C66947 NCIT_P319 "XAV9KYN9WL" @default.
- NCIT_C66947 NCIT_P322 "CTRP" @default.
- NCIT_C66947 NCIT_P322 "FDA" @default.
- NCIT_C66947 NCIT_P322 "GDC" @default.
- NCIT_C66947 NCIT_P325 "A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor." @default.
- NCIT_C66947 NCIT_P329 "534287" @default.
- NCIT_C66947 NCIT_P330 "534287" @default.
- NCIT_C66947 NCIT_P366 "AT9283" @default.
- NCIT_C66947 NCIT_P375 "Multikinase Inhibitor AT9283" @default.
- NCIT_C66947 NCIT_P399 "534287" @default.
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- NCIT_C66947 normalizedInformationContent "100" @default.
- NCIT_C66947 referenceCount "1" @default.
- NCIT_C66947 hasExactSynonym "AT-9283" @default.
- NCIT_C66947 hasExactSynonym "AT9283" @default.
- NCIT_C66947 hasExactSynonym "Aurora kinase inhibitor AT9283" @default.
- NCIT_C66947 hasExactSynonym "Multikinase Inhibitor AT9283" @default.
- NCIT_C66947 inSubset NCIT_C116977 @default.
- NCIT_C66947 inSubset NCIT_C116978 @default.
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- NCIT_C66947 inSubset NCIT_C63923 @default.
- NCIT_C66947 type Class @default.
- NCIT_C66947 isDefinedBy ncit.owl @default.
- NCIT_C66947 label "Multikinase Inhibitor AT9283" @default.
- NCIT_C66947 subClassOf B0f604a8dd80ef1987af975eda149b686 @default.
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