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- NCIT_C66954 IAO_0000115 "The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication." @default.
- NCIT_C66954 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66954 NCIT_A6 NCIT_C73305 @default.
- NCIT_C66954 NCIT_A7 NCIT_C16516 @default.
- NCIT_C66954 NCIT_NHC0 "C66954" @default.
- NCIT_C66954 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66954 NCIT_P108 "Belotecan Hydrochloride" @default.
- NCIT_C66954 NCIT_P207 "C0762739" @default.
- NCIT_C66954 NCIT_P210 "213819-48-8" @default.
- NCIT_C66954 NCIT_P319 "01DZ4127G7" @default.
- NCIT_C66954 NCIT_P322 "FDA" @default.
- NCIT_C66954 NCIT_P322 "GDC" @default.
- NCIT_C66954 NCIT_P325 "A substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor." @default.
- NCIT_C66954 NCIT_P329 "537355" @default.
- NCIT_C66954 NCIT_P330 "537355" @default.
- NCIT_C66954 NCIT_P350 "C25H27N3O4.ClH" @default.
- NCIT_C66954 NCIT_P366 "Belotecan_Hydrochloride" @default.
- NCIT_C66954 NCIT_P375 "Belotecan Hydrochloride" @default.
- NCIT_C66954 NCIT_P399 "537355" @default.
- NCIT_C66954 NCIT_R124 NCIT_C17710 @default.
- NCIT_C66954 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C66954 NCIT_R125 NCIT_C17828 @default.
- NCIT_C66954 NCIT_R125 NCIT_C19077 @default.
- NCIT_C66954 NCIT_R125 NCIT_C20480 @default.
- NCIT_C66954 NCIT_R125 NCIT_C21049 @default.
- NCIT_C66954 NCIT_R125 NCIT_C21050 @default.
- NCIT_C66954 NCIT_R125 NCIT_C21080 @default.
- NCIT_C66954 NCIT_R125 NCIT_C28498 @default.
- NCIT_C66954 NCIT_R125 NCIT_C40692 @default.
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- NCIT_C66954 NCIT_R125 NCIT_C41515 @default.
- NCIT_C66954 NCIT_R125 NCIT_C41543 @default.
- NCIT_C66954 NCIT_R146 NCIT_C16516 @default.
- NCIT_C66954 NCIT_R146 NCIT_C16554 @default.
- NCIT_C66954 NCIT_R146 NCIT_C16759 @default.
- NCIT_C66954 NCIT_R146 NCIT_C17021 @default.
- NCIT_C66954 NCIT_R146 NCIT_C20027 @default.
- NCIT_C66954 NCIT_R146 NCIT_C20646 @default.
- NCIT_C66954 NCIT_R146 NCIT_C26548 @default.
- NCIT_C66954 normalizedInformationContent "100" @default.
- NCIT_C66954 referenceCount "1" @default.
- NCIT_C66954 hasExactSynonym "BELOTECAN HYDROCHLORIDE" @default.
- NCIT_C66954 hasExactSynonym "Belotecan Hydrochloride" @default.
- NCIT_C66954 hasExactSynonym "CKD602 HCl" @default.
- NCIT_C66954 hasExactSynonym "belotecan hydrochloride" @default.
- NCIT_C66954 inSubset NCIT_C128784 @default.
- NCIT_C66954 inSubset NCIT_C157711 @default.
- NCIT_C66954 inSubset NCIT_C157712 @default.
- NCIT_C66954 inSubset NCIT_C176424 @default.
- NCIT_C66954 inSubset NCIT_C177537 @default.
- NCIT_C66954 inSubset NCIT_C63923 @default.
- NCIT_C66954 type Class @default.
- NCIT_C66954 isDefinedBy ncit.owl @default.
- NCIT_C66954 label "Belotecan Hydrochloride" @default.
- NCIT_C66954 subClassOf B35fff0a71330d6964a86a53808818eef @default.
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- NCIT_C66954 subClassOf NCIT_C129824 @default.
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- NCIT_C66954 subClassOf NCIT_C1904 @default.
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- NCIT_C66954 subClassOf NCIT_C471 @default.
- NCIT_C66954 subClassOf NCIT_C66954 @default.