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- NCIT_C66955 IAO_0000115 "A synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities. The 3alpha- and 3beta-hydroxy metabolites of tibilone activate estrogenic receptors (ERs) in bone and vaginal tissue leading to a decrease in bone turnover, and decreased vaginal dryness, respectively; derived from the 3beta-hydroxy metabolite, its delta4-isomer activates androgenic receptors (ARs) in the brain and liver and progestogenic receptors (PRs) in endometrial tissue, affecting sexual function, lipid metabolism, and endometrial function, respectively. In breast and endometrial tissue, tibolone metabolites inhibit sulfatase, preventing the conversion of circulating estrone sulfate and estradiol sulfate to estrone and estradiol, respectively; estrogen-mediated effects in the breast and uterus are thus reduced." @default.
- NCIT_C66955 NCIT_NHC0 "C66955" @default.
- NCIT_C66955 NCIT_P106 "Organic Chemical" @default.
- NCIT_C66955 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66955 NCIT_P108 "Tibolone" @default.
- NCIT_C66955 NCIT_P207 "C0076660" @default.
- NCIT_C66955 NCIT_P210 "5630-53-5" @default.
- NCIT_C66955 NCIT_P319 "FF9X0205V2" @default.
- NCIT_C66955 NCIT_P322 "FDA" @default.
- NCIT_C66955 NCIT_P329 "530794" @default.
- NCIT_C66955 NCIT_P330 "530794" @default.
- NCIT_C66955 NCIT_P350 "C21H28O2" @default.
- NCIT_C66955 NCIT_P366 "Tibolone" @default.
- NCIT_C66955 NCIT_P368 "CHEBI:32223" @default.
- NCIT_C66955 NCIT_P399 "530794" @default.
- NCIT_C66955 normalizedInformationContent "100" @default.
- NCIT_C66955 referenceCount "1" @default.
- NCIT_C66955 hasExactSynonym "Livial" @default.
- NCIT_C66955 hasExactSynonym "ORG OD 14" @default.
- NCIT_C66955 hasExactSynonym "TIBOLONE" @default.
- NCIT_C66955 hasExactSynonym "Tibolone" @default.
- NCIT_C66955 hasExactSynonym "Xyvion" @default.
- NCIT_C66955 inSubset NCIT_C176424 @default.
- NCIT_C66955 inSubset NCIT_C63923 @default.
- NCIT_C66955 type Class @default.
- NCIT_C66955 isDefinedBy ncit.owl @default.
- NCIT_C66955 label "Tibolone" @default.
- NCIT_C66955 subClassOf NCIT_C147908 @default.
- NCIT_C66955 subClassOf NCIT_C1908 @default.
- NCIT_C66955 subClassOf NCIT_C1909 @default.
- NCIT_C66955 subClassOf NCIT_C1913 @default.
- NCIT_C66955 subClassOf NCIT_C2360 @default.
- NCIT_C66955 subClassOf NCIT_C548 @default.
- NCIT_C66955 subClassOf NCIT_C616 @default.
- NCIT_C66955 subClassOf NCIT_C66955 @default.
- NCIT_C66955 subClassOf NCIT_C718 @default.
- NCIT_C66955 subClassOf NCIT_C843 @default.