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- NCIT_C66972 IAO_0000115 "A replication-defective adenoviral serotype 5 vector encoding a recombinant form of the human cytokine interferon-gamma (IFN-g), with potential antineoplastic and immunoregulatory activities. Upon intratumoral administration, the sustained expression of IFN-g by IFN-g-expressing adenovirus vaccine ASN-002 promotes a T-helper type 1 (Th1) immune response and inhibits the Th2-mediated cytokine production observed in many cutaneous lymphomas. IFN-g also mediates interleukin-12 (IL-12) production by antigen-presenting cells (APCs); activates macrophages, cytotoxic T-cells, and natural killer (NK) cells; upregulates major histocompatibility complex (MHC) molecules; and stimulates antibody-dependent cellular cytotoxicity (ADCC). Altogether, these IFN-g-mediated effects may result in both an inhibition of tumor cell proliferation and tumor cell death. Compared to IFN-g injections, the prolonged local production of IFN-g at the tumor site allows for higher efficacy and a reduction of systemic toxicity." @default.
- NCIT_C66972 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66972 NCIT_NHC0 "C66972" @default.
- NCIT_C66972 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66972 NCIT_P108 "Interferon-gamma-expressing Adenovirus Vaccine ASN-002" @default.
- NCIT_C66972 NCIT_P207 "C1832028" @default.
- NCIT_C66972 NCIT_P322 "GDC" @default.
- NCIT_C66972 NCIT_P329 "530060" @default.
- NCIT_C66972 NCIT_P330 "530060" @default.
- NCIT_C66972 NCIT_P375 "Interferon-gamma-expressing Adenovirus Vaccine ASN-002" @default.
- NCIT_C66972 NCIT_P399 "530060" @default.
- NCIT_C66972 NCIT_R125 NCIT_C16298 @default.
- NCIT_C66972 NCIT_R125 NCIT_C17709 @default.
- NCIT_C66972 NCIT_R125 NCIT_C17828 @default.
- NCIT_C66972 NCIT_R125 NCIT_C17930 @default.
- NCIT_C66972 NCIT_R125 NCIT_C17937 @default.
- NCIT_C66972 NCIT_R125 NCIT_C18839 @default.
- NCIT_C66972 NCIT_R125 NCIT_C19053 @default.
- NCIT_C66972 NCIT_R125 NCIT_C21124 @default.
- NCIT_C66972 NCIT_R125 NCIT_C26280 @default.
- NCIT_C66972 NCIT_R125 NCIT_C40833 @default.
- NCIT_C66972 normalizedInformationContent "100" @default.
- NCIT_C66972 referenceCount "1" @default.
- NCIT_C66972 hasExactSynonym "ASN-002" @default.
- NCIT_C66972 hasExactSynonym "Ad-IFNg" @default.
- NCIT_C66972 hasExactSynonym "INFg-expressing Ad Vaccine ASN-002" @default.
- NCIT_C66972 hasExactSynonym "Interferon-gamma-expressing Adenovirus Vaccine ASN-002" @default.
- NCIT_C66972 hasExactSynonym "TG1042" @default.
- NCIT_C66972 inSubset NCIT_C128784 @default.
- NCIT_C66972 inSubset NCIT_C157711 @default.
- NCIT_C66972 inSubset NCIT_C157712 @default.
- NCIT_C66972 inSubset NCIT_C176424 @default.
- NCIT_C66972 inSubset NCIT_C177537 @default.
- NCIT_C66972 type Class @default.
- NCIT_C66972 isDefinedBy ncit.owl @default.
- NCIT_C66972 label "Interferon-gamma-expressing Adenovirus Vaccine ASN-002" @default.
- NCIT_C66972 subClassOf B7b5502f94e564ea8d77d1e9869abb041 @default.
- NCIT_C66972 subClassOf Ba150afc9e6ac55ddcd3360ea42fdbe86 @default.
- NCIT_C66972 subClassOf Bb3376e9ef7553f8fd94fc2f1ebb3d8af @default.
- NCIT_C66972 subClassOf Bd5d80b63084f7344b19d1c0a78af7216 @default.
- NCIT_C66972 subClassOf NCIT_C1572 @default.
- NCIT_C66972 subClassOf NCIT_C1908 @default.
- NCIT_C66972 subClassOf NCIT_C1909 @default.
- NCIT_C66972 subClassOf NCIT_C1962 @default.
- NCIT_C66972 subClassOf NCIT_C307 @default.
- NCIT_C66972 subClassOf NCIT_C308 @default.
- NCIT_C66972 subClassOf NCIT_C49146 @default.
- NCIT_C66972 subClassOf NCIT_C66972 @default.
- NCIT_C66972 subClassOf NCIT_C923 @default.
- NCIT_C66972 subClassOf NCIT_C96404 @default.