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- NCIT_C66987 IAO_0000115 "A folate receptor-targeting cytotoxic agent with potential antineoplastic activity. Folate receptor-targeted vinca alkaloid/mitomycin C EC0225 contains two potent cytotoxic agents, a vinca alkaloid and mitomycin C, linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the cytotoxic agents directly into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. Mitomycin C alkylates DNA, producing DNA cross-links and inhibiting DNA replication. The relative tumor cell specificity of EC0225 reduces the toxicity profiles of its cytotoxic agent moieties." @default.
- NCIT_C66987 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66987 NCIT_A7 NCIT_C39284 @default.
- NCIT_C66987 NCIT_NHC0 "C66987" @default.
- NCIT_C66987 NCIT_P106 "Organic Chemical" @default.
- NCIT_C66987 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66987 NCIT_P107 "Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 NCIT_P108 "Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 NCIT_P207 "C1880433" @default.
- NCIT_C66987 NCIT_P322 "CTRP" @default.
- NCIT_C66987 NCIT_P322 "GDC" @default.
- NCIT_C66987 NCIT_P329 "539691" @default.
- NCIT_C66987 NCIT_P330 "539691" @default.
- NCIT_C66987 NCIT_P366 "EC0225" @default.
- NCIT_C66987 NCIT_P375 "Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 NCIT_P399 "539691" @default.
- NCIT_C66987 NCIT_R124 NCIT_C17828 @default.
- NCIT_C66987 NCIT_R124 NCIT_C20480 @default.
- NCIT_C66987 NCIT_R124 NCIT_C40795 @default.
- NCIT_C66987 NCIT_R124 NCIT_C40798 @default.
- NCIT_C66987 NCIT_R125 NCIT_C16397 @default.
- NCIT_C66987 NCIT_R125 NCIT_C17828 @default.
- NCIT_C66987 NCIT_R125 NCIT_C18824 @default.
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- NCIT_C66987 NCIT_R125 NCIT_C20480 @default.
- NCIT_C66987 NCIT_R125 NCIT_C21102 @default.
- NCIT_C66987 NCIT_R125 NCIT_C40715 @default.
- NCIT_C66987 NCIT_R125 NCIT_C41515 @default.
- NCIT_C66987 NCIT_R125 NCIT_C51037 @default.
- NCIT_C66987 normalizedInformationContent "100" @default.
- NCIT_C66987 referenceCount "1" @default.
- NCIT_C66987 hasExactSynonym "EC0225" @default.
- NCIT_C66987 hasExactSynonym "Folate Linked Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 hasExactSynonym "Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 inSubset NCIT_C116977 @default.
- NCIT_C66987 inSubset NCIT_C116978 @default.
- NCIT_C66987 inSubset NCIT_C128784 @default.
- NCIT_C66987 inSubset NCIT_C157711 @default.
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- NCIT_C66987 inSubset NCIT_C176424 @default.
- NCIT_C66987 inSubset NCIT_C177537 @default.
- NCIT_C66987 type Class @default.
- NCIT_C66987 isDefinedBy ncit.owl @default.
- NCIT_C66987 label "Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225" @default.
- NCIT_C66987 subClassOf B08dc7ed903913f7bc3d2a3bb591afd46 @default.
- NCIT_C66987 subClassOf B7ee94a625d117d3c5abadd52cc257382 @default.
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- NCIT_C66987 subClassOf NCIT_C1590 @default.
- NCIT_C66987 subClassOf NCIT_C163758 @default.
- NCIT_C66987 subClassOf NCIT_C186664 @default.
- NCIT_C66987 subClassOf NCIT_C1908 @default.
- NCIT_C66987 subClassOf NCIT_C1909 @default.
- NCIT_C66987 subClassOf NCIT_C200114 @default.
- NCIT_C66987 subClassOf NCIT_C259 @default.
- NCIT_C66987 subClassOf NCIT_C25974 @default.
- NCIT_C66987 subClassOf NCIT_C273 @default.
- NCIT_C66987 subClassOf NCIT_C274 @default.
- NCIT_C66987 subClassOf NCIT_C2842 @default.
- NCIT_C66987 subClassOf NCIT_C292 @default.
- NCIT_C66987 subClassOf NCIT_C663 @default.
- NCIT_C66987 subClassOf NCIT_C66987 @default.
- NCIT_C66987 subClassOf NCIT_C67422 @default.