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- NCIT_C66990 IAO_0000115 "A synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide." @default.
- NCIT_C66990 NCIT_A32 NCIT_C1909 @default.
- NCIT_C66990 NCIT_A7 NCIT_C449 @default.
- NCIT_C66990 NCIT_NHC0 "C66990" @default.
- NCIT_C66990 NCIT_P106 "Organic Chemical" @default.
- NCIT_C66990 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C66990 NCIT_P107 "Palifosfamide" @default.
- NCIT_C66990 NCIT_P108 "Palifosfamide" @default.
- NCIT_C66990 NCIT_P171 "6821629" @default.
- NCIT_C66990 NCIT_P175 "297900" @default.
- NCIT_C66990 NCIT_P207 "C0064039" @default.
- NCIT_C66990 NCIT_P210 "31645-39-3" @default.
- NCIT_C66990 NCIT_P319 "6A4U6NN813" @default.
- NCIT_C66990 NCIT_P322 "CTRP" @default.
- NCIT_C66990 NCIT_P322 "FDA" @default.
- NCIT_C66990 NCIT_P322 "GDC" @default.
- NCIT_C66990 NCIT_P329 "538996" @default.
- NCIT_C66990 NCIT_P330 "538996" @default.
- NCIT_C66990 NCIT_P350 "C4H11Cl2N2O2P" @default.
- NCIT_C66990 NCIT_P366 "Isophosphoramide_Mustard-Lysine" @default.
- NCIT_C66990 NCIT_P375 "Palifosfamide" @default.
- NCIT_C66990 NCIT_P399 "538996" @default.
- NCIT_C66990 normalizedInformationContent "100" @default.
- NCIT_C66990 referenceCount "1" @default.
- NCIT_C66990 hasExactSynonym "IPM-Lysine" @default.
- NCIT_C66990 hasExactSynonym "Isophosphoramide Mustard-Lysine" @default.
- NCIT_C66990 hasExactSynonym "N,N'-Di-(2-chloroethyl)phosphorodiamidic Acid" @default.
- NCIT_C66990 hasExactSynonym "PALIFOSFAMIDE" @default.
- NCIT_C66990 hasExactSynonym "Palifosfamide" @default.
- NCIT_C66990 hasExactSynonym "ZIO-201" @default.
- NCIT_C66990 inSubset NCIT_C116977 @default.
- NCIT_C66990 inSubset NCIT_C116978 @default.
- NCIT_C66990 inSubset NCIT_C128784 @default.
- NCIT_C66990 inSubset NCIT_C157711 @default.
- NCIT_C66990 inSubset NCIT_C157712 @default.
- NCIT_C66990 inSubset NCIT_C176424 @default.
- NCIT_C66990 inSubset NCIT_C177537 @default.
- NCIT_C66990 inSubset NCIT_C63923 @default.
- NCIT_C66990 type Class @default.
- NCIT_C66990 isDefinedBy ncit.owl @default.
- NCIT_C66990 label "Palifosfamide" @default.
- NCIT_C66990 subClassOf NCIT_C1590 @default.
- NCIT_C66990 subClassOf NCIT_C186664 @default.
- NCIT_C66990 subClassOf NCIT_C1908 @default.
- NCIT_C66990 subClassOf NCIT_C1909 @default.
- NCIT_C66990 subClassOf NCIT_C2114 @default.
- NCIT_C66990 subClassOf NCIT_C274 @default.
- NCIT_C66990 subClassOf NCIT_C2842 @default.
- NCIT_C66990 subClassOf NCIT_C66990 @default.
- NCIT_C66990 subClassOf NCIT_C697 @default.