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- NCIT_C67041 IAO_0000115 "A recombinant, soluble, hexameric fusion protein consisting of three human Fas ligand (FasL) extracellular domains fused to the dimer-forming collagen domain of human adiponectin with potential pro-apoptotic and antineoplastic activities. Assembled into a soluble hexameric structure mimicking the ligand clustering of endogenous active FasL, Fas receptor agonist APO010 activates the Fas receptor, resulting in caspase-dependent apoptosis in susceptible tumor cell populations. FasL is a transmembrane protein of the tumor necrosis factor (TNF) superfamily and a pro-apoptotic ligand for the death receptor Fas." @default.
- NCIT_C67041 NCIT_A32 NCIT_C1909 @default.
- NCIT_C67041 NCIT_NHC0 "C67041" @default.
- NCIT_C67041 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C67041 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C67041 NCIT_P108 "Fas Receptor Agonist APO010" @default.
- NCIT_C67041 NCIT_P207 "C1879517" @default.
- NCIT_C67041 NCIT_P322 "GDC" @default.
- NCIT_C67041 NCIT_P329 "539307" @default.
- NCIT_C67041 NCIT_P330 "539307" @default.
- NCIT_C67041 NCIT_P366 "APO010" @default.
- NCIT_C67041 NCIT_P375 "Fas Receptor Agonist APO010" @default.
- NCIT_C67041 NCIT_P399 "539307" @default.
- NCIT_C67041 normalizedInformationContent "100" @default.
- NCIT_C67041 referenceCount "1" @default.
- NCIT_C67041 hasExactSynonym "APO010" @default.
- NCIT_C67041 hasExactSynonym "Fas Receptor Agonist APO010" @default.
- NCIT_C67041 hasExactSynonym "Mega-FasLigand" @default.
- NCIT_C67041 inSubset NCIT_C128784 @default.
- NCIT_C67041 inSubset NCIT_C157711 @default.
- NCIT_C67041 inSubset NCIT_C157712 @default.
- NCIT_C67041 inSubset NCIT_C176424 @default.
- NCIT_C67041 inSubset NCIT_C177537 @default.
- NCIT_C67041 type Class @default.
- NCIT_C67041 isDefinedBy ncit.owl @default.
- NCIT_C67041 label "Fas Receptor Agonist APO010" @default.
- NCIT_C67041 subClassOf NCIT_C1283 @default.
- NCIT_C67041 subClassOf NCIT_C1908 @default.
- NCIT_C67041 subClassOf NCIT_C1909 @default.
- NCIT_C67041 subClassOf NCIT_C1941 @default.
- NCIT_C67041 subClassOf NCIT_C307 @default.
- NCIT_C67041 subClassOf NCIT_C308 @default.
- NCIT_C67041 subClassOf NCIT_C67041 @default.