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- NCIT_C67042 IAO_0000115 "A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors." @default.
- NCIT_C67042 NCIT_A32 NCIT_C1909 @default.
- NCIT_C67042 NCIT_NHC0 "C67042" @default.
- NCIT_C67042 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C67042 NCIT_P108 "MDR Modulator CBT-1" @default.
- NCIT_C67042 NCIT_P207 "C0916470" @default.
- NCIT_C67042 NCIT_P322 "GDC" @default.
- NCIT_C67042 NCIT_P325 "A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist." @default.
- NCIT_C67042 NCIT_P329 "538747" @default.
- NCIT_C67042 NCIT_P330 "538747" @default.
- NCIT_C67042 NCIT_P366 "CBT-1" @default.
- NCIT_C67042 NCIT_P375 "MDR Modulator CBT-1" @default.
- NCIT_C67042 NCIT_P399 "538747" @default.
- NCIT_C67042 normalizedInformationContent "100" @default.
- NCIT_C67042 referenceCount "1" @default.
- NCIT_C67042 hasExactSynonym "CBT-1" @default.
- NCIT_C67042 hasExactSynonym "MDR Modulator CBT-1" @default.
- NCIT_C67042 hasExactSynonym "MDR modulator CBT-1" @default.
- NCIT_C67042 inSubset NCIT_C128784 @default.
- NCIT_C67042 inSubset NCIT_C157711 @default.
- NCIT_C67042 inSubset NCIT_C157712 @default.
- NCIT_C67042 inSubset NCIT_C176424 @default.
- NCIT_C67042 inSubset NCIT_C177537 @default.
- NCIT_C67042 type Class @default.
- NCIT_C67042 isDefinedBy ncit.owl @default.
- NCIT_C67042 label "MDR Modulator CBT-1" @default.
- NCIT_C67042 subClassOf NCIT_C1744 @default.
- NCIT_C67042 subClassOf NCIT_C1908 @default.
- NCIT_C67042 subClassOf NCIT_C1909 @default.
- NCIT_C67042 subClassOf NCIT_C67042 @default.