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- NCIT_C67059 IAO_0000115 "The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53." @default.
- NCIT_C67059 NCIT_A32 NCIT_C1909 @default.
- NCIT_C67059 NCIT_A6 NCIT_C87656 @default.
- NCIT_C67059 NCIT_NHC0 "C67059" @default.
- NCIT_C67059 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C67059 NCIT_P107 "Quinacrine Hydrochloride" @default.
- NCIT_C67059 NCIT_P108 "Quinacrine Hydrochloride" @default.
- NCIT_C67059 NCIT_P175 "14229" @default.
- NCIT_C67059 NCIT_P208 "CL550623" @default.
- NCIT_C67059 NCIT_P210 "6151-30-0" @default.
- NCIT_C67059 NCIT_P319 "G6242H2NAA" @default.
- NCIT_C67059 NCIT_P322 "CTRP" @default.
- NCIT_C67059 NCIT_P322 "FDA" @default.
- NCIT_C67059 NCIT_P322 "GDC" @default.
- NCIT_C67059 NCIT_P329 "531122" @default.
- NCIT_C67059 NCIT_P330 "531122" @default.
- NCIT_C67059 NCIT_P350 "C23H30ClN3O.2ClH.2H2O" @default.
- NCIT_C67059 NCIT_P366 "Quinacrine_Dihydrochloride" @default.
- NCIT_C67059 NCIT_P375 "Quinacrine Hydrochloride" @default.
- NCIT_C67059 NCIT_P399 "531122" @default.
- NCIT_C67059 normalizedInformationContent "100" @default.
- NCIT_C67059 referenceCount "1" @default.
- NCIT_C67059 hasExactSynonym "6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Dihydrochloride" @default.
- NCIT_C67059 hasExactSynonym "Atabrine Dihydrochloride" @default.
- NCIT_C67059 hasExactSynonym "Mepacrine Dihydrochloride" @default.
- NCIT_C67059 hasExactSynonym "QUINACRINE HYDROCHLORIDE" @default.
- NCIT_C67059 hasExactSynonym "Quinacrine Dihydrochloride" @default.
- NCIT_C67059 hasExactSynonym "Quinacrine Hydrochloride" @default.
- NCIT_C67059 hasExactSynonym "SN 390" @default.
- NCIT_C67059 inSubset NCIT_C116977 @default.
- NCIT_C67059 inSubset NCIT_C116978 @default.
- NCIT_C67059 inSubset NCIT_C128784 @default.
- NCIT_C67059 inSubset NCIT_C157711 @default.
- NCIT_C67059 inSubset NCIT_C157712 @default.
- NCIT_C67059 inSubset NCIT_C176424 @default.
- NCIT_C67059 inSubset NCIT_C177537 @default.
- NCIT_C67059 inSubset NCIT_C63923 @default.
- NCIT_C67059 type Class @default.
- NCIT_C67059 isDefinedBy ncit.owl @default.
- NCIT_C67059 label "Quinacrine Hydrochloride" @default.
- NCIT_C67059 subClassOf NCIT_C129839 @default.
- NCIT_C67059 subClassOf NCIT_C1908 @default.
- NCIT_C67059 subClassOf NCIT_C1909 @default.
- NCIT_C67059 subClassOf NCIT_C254 @default.
- NCIT_C67059 subClassOf NCIT_C274 @default.
- NCIT_C67059 subClassOf NCIT_C276 @default.
- NCIT_C67059 subClassOf NCIT_C277 @default.
- NCIT_C67059 subClassOf NCIT_C67059 @default.