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- NCIT_C67082 IAO_0000115 "Human mesenchymal stem cells (MSCs) harvested from bone marrow of healthy adult donors and expanded ex vivo, with potential immunosuppressive application. Allogeneic adult MSCs are hypo-immunogenic due to lack of major histocompatibility II (MHC II) molecule expression, and thereby elicit none or minimal immune response upon intravenous infusion. MSCs are pluripotent, and are capable of being recruited to damaged tissue sites and differentiating along specific lineages when stimulated. Infusion of MSCs results in: a) increased production of anti-inflammatory cytokines, such as interleukin-10, prostaglandin E, and hepatocyte growth factor; b) decreased mononuclear phagocyte expression of indoleamine 2,3,-dioxygenase, which catabolizes L-tryptophan into its metabolites, which in turn contribute to inflammation; and c) modulated dendritic cell maturation and disrupted activities of natural killer cells, CD8+ and CD4+ T cells." @default.
- NCIT_C67082 NCIT_NHC0 "C67082" @default.
- NCIT_C67082 NCIT_P106 "Cell" @default.
- NCIT_C67082 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C67082 NCIT_P107 "Remestemcel-L" @default.
- NCIT_C67082 NCIT_P108 "Remestemcel-L" @default.
- NCIT_C67082 NCIT_P207 "C1879680" @default.
- NCIT_C67082 NCIT_P302 "Immunomodulator, anti-inflammatory, tissue protectant" @default.
- NCIT_C67082 NCIT_P319 "H57D26Z9YK" @default.
- NCIT_C67082 NCIT_P322 "CTRP" @default.
- NCIT_C67082 NCIT_P322 "FDA" @default.
- NCIT_C67082 NCIT_P329 "537395" @default.
- NCIT_C67082 NCIT_P330 "537395" @default.
- NCIT_C67082 NCIT_P366 "Allogeneic_Expanded_Mesenchymal_Stem_Cells" @default.
- NCIT_C67082 NCIT_P399 "537395" @default.
- NCIT_C67082 normalizedInformationContent "100" @default.
- NCIT_C67082 referenceCount "1" @default.
- NCIT_C67082 hasExactSynonym "Allogeneic Adult Mesenchymal Stem Cells" @default.
- NCIT_C67082 hasExactSynonym "Allogeneic Adults MSCs" @default.
- NCIT_C67082 hasExactSynonym "JR-0301" @default.
- NCIT_C67082 hasExactSynonym "Prochymal" @default.
- NCIT_C67082 hasExactSynonym "REMESTEMCEL-L" @default.
- NCIT_C67082 hasExactSynonym "Remestemcel-L" @default.
- NCIT_C67082 inSubset NCIT_C116977 @default.
- NCIT_C67082 inSubset NCIT_C116978 @default.
- NCIT_C67082 inSubset NCIT_C173381 @default.
- NCIT_C67082 inSubset NCIT_C173383 @default.
- NCIT_C67082 inSubset NCIT_C176424 @default.
- NCIT_C67082 inSubset NCIT_C63923 @default.
- NCIT_C67082 type Class @default.
- NCIT_C67082 isDefinedBy ncit.owl @default.
- NCIT_C67082 label "Remestemcel-L" @default.
- NCIT_C67082 subClassOf NCIT_C142078 @default.
- NCIT_C67082 subClassOf NCIT_C1908 @default.
- NCIT_C67082 subClassOf NCIT_C1909 @default.
- NCIT_C67082 subClassOf NCIT_C201556 @default.
- NCIT_C67082 subClassOf NCIT_C307 @default.
- NCIT_C67082 subClassOf NCIT_C308 @default.
- NCIT_C67082 subClassOf NCIT_C67082 @default.