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- NCIT_C67443 IAO_0000115 "A class of compounds that modulate the activity of mitotic enzymes. Mitotic enzymes regulate various mitotic events including centrosome separation, mitotic spindle assembly, chromosome alignment, phosphorylation of tubulin and cell-cycle regulators, and interaction with mitotic kinesins; other roles include facilitating the progression through and the exit from mitosis as well as regulating cytokinesis. Agents that modulate the activity of mitotic enzymes, specifically those that inhibit cytokinesis, may produce an anti-mitotic effect resulting from the aberrant formation of abnormal or polyploid cells and their subsequent exit from mitosis, which triggers apoptosis-an effect unrelated to the classical mitotic arrest described with other anti-mitotic compounds." @default.
- NCIT_C67443 NCIT_NHC0 "C67443" @default.
- NCIT_C67443 NCIT_P106 "Chemical Viewed Functionally" @default.
- NCIT_C67443 NCIT_P108 "Mitotic Enzyme Modulator" @default.
- NCIT_C67443 NCIT_P207 "C1881870" @default.
- NCIT_C67443 NCIT_P366 "Mitotic_Enzyme_Modulator" @default.
- NCIT_C67443 normalizedInformationContent "100" @default.
- NCIT_C67443 referenceCount "1" @default.
- NCIT_C67443 hasExactSynonym "Mitotic Enzyme Modulator" @default.
- NCIT_C67443 type Class @default.
- NCIT_C67443 isDefinedBy ncit.owl @default.
- NCIT_C67443 label "Mitotic Enzyme Modulator" @default.
- NCIT_C67443 subClassOf NCIT_C186664 @default.
- NCIT_C67443 subClassOf NCIT_C1908 @default.
- NCIT_C67443 subClassOf NCIT_C1909 @default.
- NCIT_C67443 subClassOf NCIT_C273 @default.
- NCIT_C67443 subClassOf NCIT_C274 @default.
- NCIT_C67443 subClassOf NCIT_C67443 @default.