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- NCIT_C67504 IAO_0000115 "A liposomal formulation containing a fixed combination of the antineoplastic agents cytarabine and daunorubicin in a 5:1 molar ratio. Liposome-encapsulated daunorubicin-cytarabine has been designed to provide optimal delivery of a specific ratio of cytarabine to daunorubicin, one that has been shown to be synergistic in vitro. The antimetabolite cytarabine competes with cytidine for incorporation into DNA, inhibiting DNA synthesis. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Daunorubicin, an intercalator and a topoisomerase II inhibitor, prevents DNA replication and inhibits protein synthesis. This agent also generates oxygen free radicals, resulting in the cytotoxic lipid peroxidation of cell membrane lipids." @default.
- NCIT_C67504 NCIT_A24 NCIT_C274 @default.
- NCIT_C67504 NCIT_A32 NCIT_C1909 @default.
- NCIT_C67504 NCIT_A7 NCIT_C18434 @default.
- NCIT_C67504 NCIT_A7 NCIT_C19172 @default.
- NCIT_C67504 NCIT_NHC0 "C67504" @default.
- NCIT_C67504 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C67504 NCIT_P107 "Liposome-encapsulated Daunorubicin-Cytarabine" @default.
- NCIT_C67504 NCIT_P108 "Liposome-encapsulated Daunorubicin-Cytarabine" @default.
- NCIT_C67504 NCIT_P208 "CL372099" @default.
- NCIT_C67504 NCIT_P302 "treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC)." @default.
- NCIT_C67504 NCIT_P322 "CTRP" @default.
- NCIT_C67504 NCIT_P322 "GDC" @default.
- NCIT_C67504 NCIT_P322 "PCDC" @default.
- NCIT_C67504 NCIT_P329 "554979" @default.
- NCIT_C67504 NCIT_P330 "554979" @default.
- NCIT_C67504 NCIT_P366 "Liposomal_Cytarabine-Daunorubicin_CPX-351" @default.
- NCIT_C67504 NCIT_P375 "Liposome-encapsulated Daunorubicin-Cytarabine" @default.
- NCIT_C67504 NCIT_P399 "554979" @default.
- NCIT_C67504 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C67504 referenceCount "2" @default.
- NCIT_C67504 hasExactSynonym "CPX-351" @default.
- NCIT_C67504 hasExactSynonym "Cytarabine and Daunorubicin Liposomal" @default.
- NCIT_C67504 hasExactSynonym "Cytarabine-Daunorubicin Liposome for Injection" @default.
- NCIT_C67504 hasExactSynonym "Daunorubicin and Cytarabine (Liposomal)" @default.
- NCIT_C67504 hasExactSynonym "Liposomal AraC-Daunorubicin CPX-351" @default.
- NCIT_C67504 hasExactSynonym "Liposomal Cytarabine-Daunorubicin" @default.
- NCIT_C67504 hasExactSynonym "Liposome-encapsulated Combination of Daunorubicin and Cytarabine" @default.
- NCIT_C67504 hasExactSynonym "Liposome-encapsulated Daunorubicin-Cytarabine" @default.
- NCIT_C67504 hasExactSynonym "Vyxeos" @default.
- NCIT_C67504 inSubset NCIT_C116977 @default.
- NCIT_C67504 inSubset NCIT_C116978 @default.
- NCIT_C67504 inSubset NCIT_C128784 @default.
- NCIT_C67504 inSubset NCIT_C157711 @default.
- NCIT_C67504 inSubset NCIT_C157712 @default.
- NCIT_C67504 inSubset NCIT_C173234 @default.
- NCIT_C67504 inSubset NCIT_C174019 @default.
- NCIT_C67504 inSubset NCIT_C176424 @default.
- NCIT_C67504 inSubset NCIT_C177537 @default.
- NCIT_C67504 type Class @default.
- NCIT_C67504 isDefinedBy ncit.owl @default.
- NCIT_C67504 label "Liposome-encapsulated Daunorubicin-Cytarabine" @default.
- NCIT_C67504 subClassOf NCIT_C129824 @default.
- NCIT_C67504 subClassOf NCIT_C129825 @default.
- NCIT_C67504 subClassOf NCIT_C1557 @default.
- NCIT_C67504 subClassOf NCIT_C1594 @default.
- NCIT_C67504 subClassOf NCIT_C1748 @default.
- NCIT_C67504 subClassOf NCIT_C186664 @default.
- NCIT_C67504 subClassOf NCIT_C1908 @default.
- NCIT_C67504 subClassOf NCIT_C1909 @default.
- NCIT_C67504 subClassOf NCIT_C1968 @default.
- NCIT_C67504 subClassOf NCIT_C2115 @default.
- NCIT_C67504 subClassOf NCIT_C2161 @default.
- NCIT_C67504 subClassOf NCIT_C2189 @default.
- NCIT_C67504 subClassOf NCIT_C259 @default.
- NCIT_C67504 subClassOf NCIT_C272 @default.
- NCIT_C67504 subClassOf NCIT_C274 @default.
- NCIT_C67504 subClassOf NCIT_C2842 @default.
- NCIT_C67504 subClassOf NCIT_C471 @default.
- NCIT_C67504 subClassOf NCIT_C67504 @default.