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- NCIT_C68814 IAO_0000115 "A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity." @default.
- NCIT_C68814 NCIT_A32 NCIT_C1909 @default.
- NCIT_C68814 NCIT_A7 NCIT_C94697 @default.
- NCIT_C68814 NCIT_NHC0 "C68814" @default.
- NCIT_C68814 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C68814 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C68814 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C68814 NCIT_P107 "Nivolumab" @default.
- NCIT_C68814 NCIT_P108 "Nivolumab" @default.
- NCIT_C68814 NCIT_P207 "C3657270" @default.
- NCIT_C68814 NCIT_P210 "946414-94-4" @default.
- NCIT_C68814 NCIT_P302 "locally advanced or metastatic urothelial carcinoma; recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN); renal cell carcinoma (RCC) ; metastatic melanoma; non-small cell lung cancer (NSCLC); classical Hodgkin lymphoma (cHL); BRAF V600 wild-type, unresectable or metastatic melanoma; metastatic small cell lung cancer (SCLC) with progression after platinum-based chemotherapy and at least one other line of therapy." @default.
- NCIT_C68814 NCIT_P319 "31YO63LBSN" @default.
- NCIT_C68814 NCIT_P322 "CTRP" @default.
- NCIT_C68814 NCIT_P322 "FDA" @default.
- NCIT_C68814 NCIT_P322 "GDC" @default.
- NCIT_C68814 NCIT_P322 "PCDC" @default.
- NCIT_C68814 NCIT_P329 "539733" @default.
- NCIT_C68814 NCIT_P330 "539733" @default.
- NCIT_C68814 NCIT_P366 "Anti-PD-1_Human_Monoclonal_Antibody_MDX-1106" @default.
- NCIT_C68814 NCIT_P375 "Nivolumab" @default.
- NCIT_C68814 NCIT_P399 "539733" @default.
- NCIT_C68814 NCIT_R124 NCIT_C17710 @default.
- NCIT_C68814 NCIT_R124 NCIT_C17828 @default.
- NCIT_C68814 NCIT_R124 NCIT_C18219 @default.
- NCIT_C68814 NCIT_R124 NCIT_C19986 @default.
- NCIT_C68814 NCIT_R124 NCIT_C40474 @default.
- NCIT_C68814 normalizedInformationContent "81.252167948509552" @default.
- NCIT_C68814 referenceCount "17" @default.
- NCIT_C68814 hasExactSynonym "ABP 206" @default.
- NCIT_C68814 hasExactSynonym "BMS-936558" @default.
- NCIT_C68814 hasExactSynonym "CMAB819" @default.
- NCIT_C68814 hasExactSynonym "MDX-1106" @default.
- NCIT_C68814 hasExactSynonym "NIVO" @default.
- NCIT_C68814 hasExactSynonym "NIVOLUMAB" @default.
- NCIT_C68814 hasExactSynonym "Nivolumab Biosimilar ABP 206" @default.
- NCIT_C68814 hasExactSynonym "Nivolumab Biosimilar CMAB819" @default.
- NCIT_C68814 hasExactSynonym "Nivolumab" @default.
- NCIT_C68814 hasExactSynonym "ONO-4538" @default.
- NCIT_C68814 hasExactSynonym "Opdivo" @default.
- NCIT_C68814 inSubset NCIT_C116977 @default.
- NCIT_C68814 inSubset NCIT_C116978 @default.
- NCIT_C68814 inSubset NCIT_C128784 @default.
- NCIT_C68814 inSubset NCIT_C157711 @default.
- NCIT_C68814 inSubset NCIT_C157712 @default.
- NCIT_C68814 inSubset NCIT_C173381 @default.
- NCIT_C68814 inSubset NCIT_C173383 @default.
- NCIT_C68814 inSubset NCIT_C176424 @default.
- NCIT_C68814 inSubset NCIT_C177537 @default.
- NCIT_C68814 inSubset NCIT_C186327 @default.
- NCIT_C68814 inSubset NCIT_C186328 @default.
- NCIT_C68814 inSubset NCIT_C186341 @default.
- NCIT_C68814 inSubset NCIT_C63923 @default.
- NCIT_C68814 type Class @default.
- NCIT_C68814 isDefinedBy ncit.owl @default.
- NCIT_C68814 label "Nivolumab" @default.
- NCIT_C68814 subClassOf NCIT_C124946 @default.
- NCIT_C68814 subClassOf NCIT_C128037 @default.
- NCIT_C68814 subClassOf NCIT_C129821 @default.
- NCIT_C68814 subClassOf NCIT_C129822 @default.
- NCIT_C68814 subClassOf NCIT_C141144 @default.
- NCIT_C68814 subClassOf NCIT_C143250 @default.
- NCIT_C68814 subClassOf NCIT_C163758 @default.
- NCIT_C68814 subClassOf NCIT_C1908 @default.
- NCIT_C68814 subClassOf NCIT_C1909 @default.
- NCIT_C68814 subClassOf NCIT_C20401 @default.
- NCIT_C68814 subClassOf NCIT_C274 @default.
- NCIT_C68814 subClassOf NCIT_C307 @default.
- NCIT_C68814 subClassOf NCIT_C308 @default.
- NCIT_C68814 subClassOf NCIT_C68814 @default.