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- NCIT_C68842 IAO_0000115 "An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both molecules are important in cognate co-stimulatory cell-cell interactions." @default.
- NCIT_C68842 NCIT_A7 NCIT_C20528 @default.
- NCIT_C68842 NCIT_NHC0 "C68842" @default.
- NCIT_C68842 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C68842 NCIT_P107 "Autologous Ad-CD154-Transduced CLL B Cells" @default.
- NCIT_C68842 NCIT_P108 "Autologous Ad-CD154-Transduced CLL B Cells" @default.
- NCIT_C68842 NCIT_P208 "CL374420" @default.
- NCIT_C68842 NCIT_P322 "CTRP" @default.
- NCIT_C68842 NCIT_P329 "552982" @default.
- NCIT_C68842 NCIT_P330 "552982" @default.
- NCIT_C68842 NCIT_P366 "Autologous_Ad-CD154-Transduced_CLL_B_Cells" @default.
- NCIT_C68842 NCIT_P399 "552982" @default.
- NCIT_C68842 normalizedInformationContent "100" @default.
- NCIT_C68842 referenceCount "1" @default.
- NCIT_C68842 hasExactSynonym "Autologous Ad-CD154-Transduced CLL B Cells" @default.
- NCIT_C68842 hasExactSynonym "L-Vax" @default.
- NCIT_C68842 inSubset NCIT_C116977 @default.
- NCIT_C68842 inSubset NCIT_C116978 @default.
- NCIT_C68842 inSubset NCIT_C128784 @default.
- NCIT_C68842 inSubset NCIT_C176424 @default.
- NCIT_C68842 type Class @default.
- NCIT_C68842 isDefinedBy ncit.owl @default.
- NCIT_C68842 label "Autologous Ad-CD154-Transduced CLL B Cells" @default.
- NCIT_C68842 subClassOf NCIT_C129820 @default.
- NCIT_C68842 subClassOf NCIT_C129821 @default.
- NCIT_C68842 subClassOf NCIT_C129826 @default.
- NCIT_C68842 subClassOf NCIT_C142078 @default.
- NCIT_C68842 subClassOf NCIT_C1663 @default.
- NCIT_C68842 subClassOf NCIT_C1908 @default.
- NCIT_C68842 subClassOf NCIT_C1909 @default.
- NCIT_C68842 subClassOf NCIT_C1980 @default.
- NCIT_C68842 subClassOf NCIT_C2023 @default.
- NCIT_C68842 subClassOf NCIT_C2341 @default.
- NCIT_C68842 subClassOf NCIT_C274 @default.
- NCIT_C68842 subClassOf NCIT_C307 @default.
- NCIT_C68842 subClassOf NCIT_C308 @default.
- NCIT_C68842 subClassOf NCIT_C68842 @default.
- NCIT_C68842 subClassOf NCIT_C923 @default.