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- NCIT_C68921 IAO_0000115 "A 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hypervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity." @default.
- NCIT_C68921 NCIT_A32 NCIT_C1909 @default.
- NCIT_C68921 NCIT_A5 NCIT_C142909 @default.
- NCIT_C68921 NCIT_NHC0 "C68921" @default.
- NCIT_C68921 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C68921 NCIT_P107 "Aldoxorubicin" @default.
- NCIT_C68921 NCIT_P108 "Aldoxorubicin" @default.
- NCIT_C68921 NCIT_P207 "C3495619" @default.
- NCIT_C68921 NCIT_P210 "1361644-26-9" @default.
- NCIT_C68921 NCIT_P319 "C28MV4IM0B" @default.
- NCIT_C68921 NCIT_P322 "CTRP" @default.
- NCIT_C68921 NCIT_P322 "FDA" @default.
- NCIT_C68921 NCIT_P322 "GDC" @default.
- NCIT_C68921 NCIT_P329 "552648" @default.
- NCIT_C68921 NCIT_P330 "552648" @default.
- NCIT_C68921 NCIT_P366 "Doxorubicin_Prodrug_INNO-206" @default.
- NCIT_C68921 NCIT_P375 "Aldoxorubicin" @default.
- NCIT_C68921 NCIT_P399 "552648" @default.
- NCIT_C68921 normalizedInformationContent "100" @default.
- NCIT_C68921 referenceCount "1" @default.
- NCIT_C68921 hasExactSynonym "ALDOXORUBICIN" @default.
- NCIT_C68921 hasExactSynonym "Aldoxorubicin" @default.
- NCIT_C68921 hasExactSynonym "DOXO-EMCH" @default.
- NCIT_C68921 hasExactSynonym "Doxorubicin-EMCH" @default.
- NCIT_C68921 hasExactSynonym "INNO-206" @default.
- NCIT_C68921 inSubset NCIT_C116977 @default.
- NCIT_C68921 inSubset NCIT_C116978 @default.
- NCIT_C68921 inSubset NCIT_C128784 @default.
- NCIT_C68921 inSubset NCIT_C157711 @default.
- NCIT_C68921 inSubset NCIT_C157712 @default.
- NCIT_C68921 inSubset NCIT_C176424 @default.
- NCIT_C68921 inSubset NCIT_C177537 @default.
- NCIT_C68921 inSubset NCIT_C63923 @default.
- NCIT_C68921 type Class @default.
- NCIT_C68921 isDefinedBy ncit.owl @default.
- NCIT_C68921 label "Aldoxorubicin" @default.
- NCIT_C68921 subClassOf NCIT_C129824 @default.
- NCIT_C68921 subClassOf NCIT_C129825 @default.
- NCIT_C68921 subClassOf NCIT_C1594 @default.
- NCIT_C68921 subClassOf NCIT_C1748 @default.
- NCIT_C68921 subClassOf NCIT_C186664 @default.
- NCIT_C68921 subClassOf NCIT_C1908 @default.
- NCIT_C68921 subClassOf NCIT_C1909 @default.
- NCIT_C68921 subClassOf NCIT_C1968 @default.
- NCIT_C68921 subClassOf NCIT_C2115 @default.
- NCIT_C68921 subClassOf NCIT_C2161 @default.
- NCIT_C68921 subClassOf NCIT_C2189 @default.
- NCIT_C68921 subClassOf NCIT_C259 @default.
- NCIT_C68921 subClassOf NCIT_C274 @default.
- NCIT_C68921 subClassOf NCIT_C2842 @default.
- NCIT_C68921 subClassOf NCIT_C471 @default.
- NCIT_C68921 subClassOf NCIT_C67502 @default.
- NCIT_C68921 subClassOf NCIT_C68921 @default.