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- NCIT_C68923 IAO_0000115 "An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases." @default.
- NCIT_C68923 NCIT_A32 NCIT_C1909 @default.
- NCIT_C68923 NCIT_NHC0 "C68923" @default.
- NCIT_C68923 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C68923 NCIT_P107 "Cobimetinib" @default.
- NCIT_C68923 NCIT_P108 "Cobimetinib" @default.
- NCIT_C68923 NCIT_P207 "C2346910" @default.
- NCIT_C68923 NCIT_P210 "934660-93-2" @default.
- NCIT_C68923 NCIT_P302 "unresectable or metastatic melanoma with BRAF V600E or V600K mutation" @default.
- NCIT_C68923 NCIT_P319 "ER29L26N1X" @default.
- NCIT_C68923 NCIT_P322 "CTRP" @default.
- NCIT_C68923 NCIT_P322 "FDA" @default.
- NCIT_C68923 NCIT_P322 "GDC" @default.
- NCIT_C68923 NCIT_P329 "551654" @default.
- NCIT_C68923 NCIT_P330 "551654" @default.
- NCIT_C68923 NCIT_P366 "MEK_Inhibitor_XL518" @default.
- NCIT_C68923 NCIT_P375 "Cobimetinib" @default.
- NCIT_C68923 NCIT_P399 "551654" @default.
- NCIT_C68923 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C68923 referenceCount "3" @default.
- NCIT_C68923 hasExactSynonym "COBIMETINIB" @default.
- NCIT_C68923 hasExactSynonym "Cobimetinib" @default.
- NCIT_C68923 hasExactSynonym "Cotellic" @default.
- NCIT_C68923 hasExactSynonym "GDC-0973" @default.
- NCIT_C68923 hasExactSynonym "MEK Inhibitor GDC-0973" @default.
- NCIT_C68923 hasExactSynonym "XL518" @default.
- NCIT_C68923 inSubset NCIT_C116977 @default.
- NCIT_C68923 inSubset NCIT_C116978 @default.
- NCIT_C68923 inSubset NCIT_C128784 @default.
- NCIT_C68923 inSubset NCIT_C157711 @default.
- NCIT_C68923 inSubset NCIT_C157712 @default.
- NCIT_C68923 inSubset NCIT_C176424 @default.
- NCIT_C68923 inSubset NCIT_C177537 @default.
- NCIT_C68923 inSubset NCIT_C63923 @default.
- NCIT_C68923 type Class @default.
- NCIT_C68923 isDefinedBy ncit.owl @default.
- NCIT_C68923 label "Cobimetinib" @default.
- NCIT_C68923 subClassOf NCIT_C129824 @default.
- NCIT_C68923 subClassOf NCIT_C129825 @default.
- NCIT_C68923 subClassOf NCIT_C1404 @default.
- NCIT_C68923 subClassOf NCIT_C163758 @default.
- NCIT_C68923 subClassOf NCIT_C1908 @default.
- NCIT_C68923 subClassOf NCIT_C1909 @default.
- NCIT_C68923 subClassOf NCIT_C2189 @default.
- NCIT_C68923 subClassOf NCIT_C274 @default.
- NCIT_C68923 subClassOf NCIT_C471 @default.
- NCIT_C68923 subClassOf NCIT_C68923 @default.
- NCIT_C68923 subClassOf NCIT_C69145 @default.