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- NCIT_C68929 IAO_0000115 "A synthetic molecule that targets multiple tyrosine kinases with potential antineoplastic activity. Tyrosine kinase inhibitor XL228 binds to and inhibits the activities of multiple tyrosine kinases, such as the insulin-like growth factor 1 receptor (IGF1R), Src tyrosine kinase, and Bcr-Abl tyrosine kinase. Blockade of these kinases may result in the inhibition of tumor angiogenesis, cell proliferation, and metastasis. In addition, this agent may be a potent inhibitor of the T315I mutant form of the Abl protein, which is associated with the resistance of chronic myelogenous leukemia (CML) to other tyrosine kinase inhibitors. IGF1R and Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis. Bcr-Abl translocation leads to constitutive activation of ABL kinase and is commonly associated with Philadelphia-positive acute lymphocytic leukemia (ALL)." @default.
- NCIT_C68929 NCIT_A32 NCIT_C1909 @default.
- NCIT_C68929 NCIT_A7 NCIT_C16325 @default.
- NCIT_C68929 NCIT_A7 NCIT_C17389 @default.
- NCIT_C68929 NCIT_A7 NCIT_C17531 @default.
- NCIT_C68929 NCIT_NHC0 "C68929" @default.
- NCIT_C68929 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C68929 NCIT_P107 "Tyrosine Kinase Inhibitor XL228" @default.
- NCIT_C68929 NCIT_P108 "Tyrosine Kinase Inhibitor XL228" @default.
- NCIT_C68929 NCIT_P208 "CL374367" @default.
- NCIT_C68929 NCIT_P210 "898280-07-4" @default.
- NCIT_C68929 NCIT_P319 "33M2XSK003" @default.
- NCIT_C68929 NCIT_P322 "CTRP" @default.
- NCIT_C68929 NCIT_P322 "FDA" @default.
- NCIT_C68929 NCIT_P322 "GDC" @default.
- NCIT_C68929 NCIT_P329 "549001" @default.
- NCIT_C68929 NCIT_P330 "549001" @default.
- NCIT_C68929 NCIT_P366 "Tyrosine_Kinase_Inhibitor_XL228" @default.
- NCIT_C68929 NCIT_P375 "Tyrosine Kinase Inhibitor XL228" @default.
- NCIT_C68929 NCIT_P399 "549001" @default.
- NCIT_C68929 normalizedInformationContent "100" @default.
- NCIT_C68929 referenceCount "1" @default.
- NCIT_C68929 hasExactSynonym "Tyrosine Kinase Inhibitor XL228" @default.
- NCIT_C68929 hasExactSynonym "XL-228" @default.
- NCIT_C68929 hasExactSynonym "XL228" @default.
- NCIT_C68929 inSubset NCIT_C116977 @default.
- NCIT_C68929 inSubset NCIT_C116978 @default.
- NCIT_C68929 inSubset NCIT_C128784 @default.
- NCIT_C68929 inSubset NCIT_C157711 @default.
- NCIT_C68929 inSubset NCIT_C157712 @default.
- NCIT_C68929 inSubset NCIT_C176424 @default.
- NCIT_C68929 inSubset NCIT_C177537 @default.
- NCIT_C68929 inSubset NCIT_C63923 @default.
- NCIT_C68929 type Class @default.
- NCIT_C68929 isDefinedBy ncit.owl @default.
- NCIT_C68929 label "Tyrosine Kinase Inhibitor XL228" @default.
- NCIT_C68929 subClassOf NCIT_C129824 @default.
- NCIT_C68929 subClassOf NCIT_C129825 @default.
- NCIT_C68929 subClassOf NCIT_C1404 @default.
- NCIT_C68929 subClassOf NCIT_C1908 @default.
- NCIT_C68929 subClassOf NCIT_C1909 @default.
- NCIT_C68929 subClassOf NCIT_C1967 @default.
- NCIT_C68929 subClassOf NCIT_C2189 @default.
- NCIT_C68929 subClassOf NCIT_C274 @default.
- NCIT_C68929 subClassOf NCIT_C471 @default.
- NCIT_C68929 subClassOf NCIT_C68929 @default.