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- NCIT_C68937 IAO_0000115 "A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. Filanesib specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis." @default.
- NCIT_C68937 NCIT_A32 NCIT_C1909 @default.
- NCIT_C68937 NCIT_NHC0 "C68937" @default.
- NCIT_C68937 NCIT_P106 "Organic Chemical" @default.
- NCIT_C68937 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C68937 NCIT_P107 "Filanesib" @default.
- NCIT_C68937 NCIT_P108 "Filanesib" @default.
- NCIT_C68937 NCIT_P207 "C2346611" @default.
- NCIT_C68937 NCIT_P210 "885060-09-3" @default.
- NCIT_C68937 NCIT_P319 "8A49OSO368" @default.
- NCIT_C68937 NCIT_P322 "CTRP" @default.
- NCIT_C68937 NCIT_P322 "FDA" @default.
- NCIT_C68937 NCIT_P322 "GDC" @default.
- NCIT_C68937 NCIT_P329 "546990" @default.
- NCIT_C68937 NCIT_P330 "546990" @default.
- NCIT_C68937 NCIT_P366 "KSP_Inhibitor_ARRY-520" @default.
- NCIT_C68937 NCIT_P375 "Filanesib" @default.
- NCIT_C68937 NCIT_P399 "546990" @default.
- NCIT_C68937 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C68937 NCIT_R146 NCIT_C26548 @default.
- NCIT_C68937 NCIT_R146 NCIT_C48872 @default.
- NCIT_C68937 normalizedInformationContent "100" @default.
- NCIT_C68937 referenceCount "1" @default.
- NCIT_C68937 hasExactSynonym "1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)-" @default.
- NCIT_C68937 hasExactSynonym "ARRY-520" @default.
- NCIT_C68937 hasExactSynonym "ARRY520" @default.
- NCIT_C68937 hasExactSynonym "FILANESIB" @default.
- NCIT_C68937 hasExactSynonym "Filanesib" @default.
- NCIT_C68937 inSubset NCIT_C116977 @default.
- NCIT_C68937 inSubset NCIT_C116978 @default.
- NCIT_C68937 inSubset NCIT_C128784 @default.
- NCIT_C68937 inSubset NCIT_C157711 @default.
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- NCIT_C68937 inSubset NCIT_C176424 @default.
- NCIT_C68937 inSubset NCIT_C177537 @default.
- NCIT_C68937 inSubset NCIT_C63923 @default.
- NCIT_C68937 type Class @default.
- NCIT_C68937 isDefinedBy ncit.owl @default.
- NCIT_C68937 label "Filanesib" @default.
- NCIT_C68937 subClassOf B4f8dacd561af3945b9248919f65c5628 @default.
- NCIT_C68937 subClassOf B62be7de31bcc7a3aaaaa16e6c60acd6c @default.
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- NCIT_C68937 subClassOf NCIT_C186664 @default.
- NCIT_C68937 subClassOf NCIT_C1908 @default.
- NCIT_C68937 subClassOf NCIT_C1909 @default.
- NCIT_C68937 subClassOf NCIT_C273 @default.
- NCIT_C68937 subClassOf NCIT_C274 @default.
- NCIT_C68937 subClassOf NCIT_C67440 @default.
- NCIT_C68937 subClassOf NCIT_C68937 @default.