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- NCIT_C69005 IAO_0000115 "A synthetic urethane derivative of pladienolide D with potential antineoplastic activity. Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107. This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein 130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes." @default.
- NCIT_C69005 NCIT_A32 NCIT_C1909 @default.
- NCIT_C69005 NCIT_A7 NCIT_C181985 @default.
- NCIT_C69005 NCIT_NHC0 "C69005" @default.
- NCIT_C69005 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C69005 NCIT_P107 "Pladienolide Derivative E7107" @default.
- NCIT_C69005 NCIT_P108 "Pladienolide Derivative E7107" @default.
- NCIT_C69005 NCIT_P208 "CL375254" @default.
- NCIT_C69005 NCIT_P210 "630100-90-2" @default.
- NCIT_C69005 NCIT_P319 "R60DZX1E2N" @default.
- NCIT_C69005 NCIT_P322 "CTRP" @default.
- NCIT_C69005 NCIT_P322 "FDA" @default.
- NCIT_C69005 NCIT_P322 "GDC" @default.
- NCIT_C69005 NCIT_P329 "546981" @default.
- NCIT_C69005 NCIT_P330 "546981" @default.
- NCIT_C69005 NCIT_P350 "C40H66N2O9" @default.
- NCIT_C69005 NCIT_P366 "Pladienolide_Derivative_E7107" @default.
- NCIT_C69005 NCIT_P375 "Pladienolide Derivative E7107" @default.
- NCIT_C69005 NCIT_P399 "546981" @default.
- NCIT_C69005 normalizedInformationContent "100" @default.
- NCIT_C69005 referenceCount "1" @default.
- NCIT_C69005 hasExactSynonym "E7107" @default.
- NCIT_C69005 hasExactSynonym "Pladienolide Derivative E7107" @default.
- NCIT_C69005 inSubset NCIT_C116977 @default.
- NCIT_C69005 inSubset NCIT_C116978 @default.
- NCIT_C69005 inSubset NCIT_C128784 @default.
- NCIT_C69005 inSubset NCIT_C157711 @default.
- NCIT_C69005 inSubset NCIT_C157712 @default.
- NCIT_C69005 inSubset NCIT_C176424 @default.
- NCIT_C69005 inSubset NCIT_C177537 @default.
- NCIT_C69005 inSubset NCIT_C63923 @default.
- NCIT_C69005 type Class @default.
- NCIT_C69005 isDefinedBy ncit.owl @default.
- NCIT_C69005 label "Pladienolide Derivative E7107" @default.
- NCIT_C69005 subClassOf NCIT_C186664 @default.
- NCIT_C69005 subClassOf NCIT_C1908 @default.
- NCIT_C69005 subClassOf NCIT_C1909 @default.
- NCIT_C69005 subClassOf NCIT_C1913 @default.
- NCIT_C69005 subClassOf NCIT_C200714 @default.
- NCIT_C69005 subClassOf NCIT_C259 @default.
- NCIT_C69005 subClassOf NCIT_C274 @default.
- NCIT_C69005 subClassOf NCIT_C606 @default.
- NCIT_C69005 subClassOf NCIT_C67445 @default.
- NCIT_C69005 subClassOf NCIT_C69005 @default.
- NCIT_C69005 subClassOf NCIT_C718 @default.
- NCIT_C69005 subClassOf NCIT_C94712 @default.