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- NCIT_C69076 IAO_0000115 "A cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with rindopepimut may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro." @default.
- NCIT_C69076 NCIT_A32 NCIT_C1909 @default.
- NCIT_C69076 NCIT_A7 NCIT_C101140 @default.
- NCIT_C69076 NCIT_NHC0 "C69076" @default.
- NCIT_C69076 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C69076 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C69076 NCIT_P107 "Rindopepimut" @default.
- NCIT_C69076 NCIT_P108 "Rindopepimut" @default.
- NCIT_C69076 NCIT_P207 "C3181262" @default.
- NCIT_C69076 NCIT_P210 "946156-74-7" @default.
- NCIT_C69076 NCIT_P302 "Immunotherapy for glioblastoma multiforme" @default.
- NCIT_C69076 NCIT_P319 "K3L4X0501F" @default.
- NCIT_C69076 NCIT_P322 "CTRP" @default.
- NCIT_C69076 NCIT_P322 "FDA" @default.
- NCIT_C69076 NCIT_P322 "GDC" @default.
- NCIT_C69076 NCIT_P329 "546970" @default.
- NCIT_C69076 NCIT_P330 "546970" @default.
- NCIT_C69076 NCIT_P366 "Anti-EGFRvIII_Vaccine_CDX-110" @default.
- NCIT_C69076 NCIT_P375 "Rindopepimut" @default.
- NCIT_C69076 NCIT_P399 "546970" @default.
- NCIT_C69076 normalizedInformationContent "100" @default.
- NCIT_C69076 referenceCount "1" @default.
- NCIT_C69076 hasExactSynonym "Anti-EGFRvIII Vaccine CDX-110" @default.
- NCIT_C69076 hasExactSynonym "CDX-110" @default.
- NCIT_C69076 hasExactSynonym "L-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Megathura crenulata)" @default.
- NCIT_C69076 hasExactSynonym "PF-04948568" @default.
- NCIT_C69076 hasExactSynonym "RINDOPEPIMUT" @default.
- NCIT_C69076 hasExactSynonym "Rindopepimut" @default.
- NCIT_C69076 inSubset NCIT_C116977 @default.
- NCIT_C69076 inSubset NCIT_C116978 @default.
- NCIT_C69076 inSubset NCIT_C128784 @default.
- NCIT_C69076 inSubset NCIT_C157711 @default.
- NCIT_C69076 inSubset NCIT_C157712 @default.
- NCIT_C69076 inSubset NCIT_C176424 @default.
- NCIT_C69076 inSubset NCIT_C177537 @default.
- NCIT_C69076 inSubset NCIT_C63923 @default.
- NCIT_C69076 type Class @default.
- NCIT_C69076 isDefinedBy ncit.owl @default.
- NCIT_C69076 label "Rindopepimut" @default.
- NCIT_C69076 subClassOf NCIT_C129820 @default.
- NCIT_C69076 subClassOf NCIT_C1663 @default.
- NCIT_C69076 subClassOf NCIT_C1908 @default.
- NCIT_C69076 subClassOf NCIT_C1909 @default.
- NCIT_C69076 subClassOf NCIT_C274 @default.
- NCIT_C69076 subClassOf NCIT_C307 @default.
- NCIT_C69076 subClassOf NCIT_C308 @default.
- NCIT_C69076 subClassOf NCIT_C69076 @default.
- NCIT_C69076 subClassOf NCIT_C923 @default.