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- NCIT_C691 IAO_0000115 "A plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting." @default.
- NCIT_C691 NCIT_NHC0 "C691" @default.
- NCIT_C691 NCIT_P106 "Organic Chemical" @default.
- NCIT_C691 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C691 NCIT_P107 "Nicotine" @default.
- NCIT_C691 NCIT_P108 "Nicotine" @default.
- NCIT_C691 NCIT_P175 "5065" @default.
- NCIT_C691 NCIT_P207 "C0028040" @default.
- NCIT_C691 NCIT_P210 "54-11-5" @default.
- NCIT_C691 NCIT_P302 "Smoking Cessation" @default.
- NCIT_C691 NCIT_P319 "6M3C89ZY6R" @default.
- NCIT_C691 NCIT_P322 "CTRP" @default.
- NCIT_C691 NCIT_P322 "FDA" @default.
- NCIT_C691 NCIT_P325 "An addictive, poisonous chemical found in tobacco. It can also be made in the laboratory. When it enters the body, nicotine causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. It is also used as an insecticide." @default.
- NCIT_C691 NCIT_P329 "42243" @default.
- NCIT_C691 NCIT_P330 "42243" @default.
- NCIT_C691 NCIT_P350 "C10H14N2" @default.
- NCIT_C691 NCIT_P366 "Nicotine" @default.
- NCIT_C691 NCIT_P368 "CHEBI:17688" @default.
- NCIT_C691 NCIT_P399 "42243" @default.
- NCIT_C691 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C691 referenceCount "2" @default.
- NCIT_C691 hasExactSynonym "(-)-Nicotine" @default.
- NCIT_C691 hasExactSynonym "(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine" @default.
- NCIT_C691 hasExactSynonym "1-Methyl-2-(3-pyridyl)pyrrolidine" @default.
- NCIT_C691 hasExactSynonym "NIC" @default.
- NCIT_C691 hasExactSynonym "NICOTINE" @default.
- NCIT_C691 hasExactSynonym "Nicotine" @default.
- NCIT_C691 hasExactSynonym "beta-Pyridyl-alpha-N-methylpyrrolidine" @default.
- NCIT_C691 hasExactSynonym "nicotine" @default.
- NCIT_C691 inSubset NCIT_C116977 @default.
- NCIT_C691 inSubset NCIT_C116978 @default.
- NCIT_C691 inSubset NCIT_C142799 @default.
- NCIT_C691 inSubset NCIT_C176424 @default.
- NCIT_C691 inSubset NCIT_C63923 @default.
- NCIT_C691 type Class @default.
- NCIT_C691 isDefinedBy ncit.owl @default.
- NCIT_C691 label "Nicotine" @default.
- NCIT_C691 subClassOf NCIT_C1908 @default.
- NCIT_C691 subClassOf NCIT_C1909 @default.
- NCIT_C691 subClassOf NCIT_C1913 @default.
- NCIT_C691 subClassOf NCIT_C1916 @default.
- NCIT_C691 subClassOf NCIT_C221 @default.
- NCIT_C691 subClassOf NCIT_C47796 @default.
- NCIT_C691 subClassOf NCIT_C691 @default.
- NCIT_C691 subClassOf NCIT_C718 @default.
- NCIT_C691 subClassOf NCIT_C73579 @default.
- NCIT_C691 subClassOf NCIT_C78272 @default.