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- NCIT_C69139 IAO_0000115 "An agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. HSP90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses." @default.
- NCIT_C69139 NCIT_A32 NCIT_C1909 @default.
- NCIT_C69139 NCIT_A7 NCIT_C17766 @default.
- NCIT_C69139 NCIT_NHC0 "C69139" @default.
- NCIT_C69139 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C69139 NCIT_P107 "Hsp90 Antagonist KW-2478" @default.
- NCIT_C69139 NCIT_P108 "Hsp90 Antagonist KW-2478" @default.
- NCIT_C69139 NCIT_P207 "C2348995" @default.
- NCIT_C69139 NCIT_P210 "819812-18-5" @default.
- NCIT_C69139 NCIT_P319 "E628ZH6U2C" @default.
- NCIT_C69139 NCIT_P322 "CTRP" @default.
- NCIT_C69139 NCIT_P322 "FDA" @default.
- NCIT_C69139 NCIT_P322 "GDC" @default.
- NCIT_C69139 NCIT_P329 "548017" @default.
- NCIT_C69139 NCIT_P330 "548017" @default.
- NCIT_C69139 NCIT_P366 "Hsp90_Antagonist_KW-2478" @default.
- NCIT_C69139 NCIT_P375 "Hsp90 Antagonist KW-2478" @default.
- NCIT_C69139 NCIT_P399 "548017" @default.
- NCIT_C69139 NCIT_R125 NCIT_C17828 @default.
- NCIT_C69139 NCIT_R125 NCIT_C20150 @default.
- NCIT_C69139 NCIT_R125 NCIT_C20480 @default.
- NCIT_C69139 NCIT_R125 NCIT_C40715 @default.
- NCIT_C69139 NCIT_R125 NCIT_C41515 @default.
- NCIT_C69139 NCIT_R125 NCIT_C51037 @default.
- NCIT_C69139 normalizedInformationContent "100" @default.
- NCIT_C69139 referenceCount "1" @default.
- NCIT_C69139 hasExactSynonym "Hsp90 Antagonist KW-2478" @default.
- NCIT_C69139 hasExactSynonym "KW-2478" @default.
- NCIT_C69139 inSubset NCIT_C116977 @default.
- NCIT_C69139 inSubset NCIT_C116978 @default.
- NCIT_C69139 inSubset NCIT_C128784 @default.
- NCIT_C69139 inSubset NCIT_C157711 @default.
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- NCIT_C69139 inSubset NCIT_C176424 @default.
- NCIT_C69139 inSubset NCIT_C177537 @default.
- NCIT_C69139 inSubset NCIT_C63923 @default.
- NCIT_C69139 type Class @default.
- NCIT_C69139 isDefinedBy ncit.owl @default.
- NCIT_C69139 label "Hsp90 Antagonist KW-2478" @default.
- NCIT_C69139 subClassOf B4e54daf4d700441f58c2d8f0f098f8e2 @default.
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- NCIT_C69139 subClassOf NCIT_C156880 @default.
- NCIT_C69139 subClassOf NCIT_C1908 @default.
- NCIT_C69139 subClassOf NCIT_C1909 @default.
- NCIT_C69139 subClassOf NCIT_C2189 @default.
- NCIT_C69139 subClassOf NCIT_C274 @default.
- NCIT_C69139 subClassOf NCIT_C69139 @default.
- NCIT_C69139 subClassOf NCIT_C74526 @default.