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- NCIT_C692 IAO_0000115 "A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents." @default.
- NCIT_C692 NCIT_A32 NCIT_C1909 @default.
- NCIT_C692 NCIT_NHC0 "C692" @default.
- NCIT_C692 NCIT_P106 "Organic Chemical" @default.
- NCIT_C692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C692 NCIT_P108 "Nimodipine" @default.
- NCIT_C692 NCIT_P207 "C0678207" @default.
- NCIT_C692 NCIT_P210 "66085-59-4" @default.
- NCIT_C692 NCIT_P319 "57WA9QZ5WH" @default.
- NCIT_C692 NCIT_P322 "FDA" @default.
- NCIT_C692 NCIT_P322 "GDC" @default.
- NCIT_C692 NCIT_P325 "Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy." @default.
- NCIT_C692 NCIT_P329 "41210" @default.
- NCIT_C692 NCIT_P330 "41210" @default.
- NCIT_C692 NCIT_P350 "C21H26N2O7" @default.
- NCIT_C692 NCIT_P366 "Nimodipine" @default.
- NCIT_C692 NCIT_P368 "CHEBI:7575" @default.
- NCIT_C692 NCIT_P375 "Nimodipine" @default.
- NCIT_C692 NCIT_P399 "41210" @default.
- NCIT_C692 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C692 referenceCount "3" @default.
- NCIT_C692 hasExactSynonym "NIMO" @default.
- NCIT_C692 hasExactSynonym "NIMODIPINE" @default.
- NCIT_C692 hasExactSynonym "Nimodipine" @default.
- NCIT_C692 hasExactSynonym "Nimotop" @default.
- NCIT_C692 hasExactSynonym "nimodipine" @default.
- NCIT_C692 inSubset NCIT_C128784 @default.
- NCIT_C692 inSubset NCIT_C157711 @default.
- NCIT_C692 inSubset NCIT_C157712 @default.
- NCIT_C692 inSubset NCIT_C176424 @default.
- NCIT_C692 inSubset NCIT_C177537 @default.
- NCIT_C692 inSubset NCIT_C63923 @default.
- NCIT_C692 type Class @default.
- NCIT_C692 isDefinedBy ncit.owl @default.
- NCIT_C692 label "Nimodipine" @default.
- NCIT_C692 subClassOf NCIT_C1908 @default.
- NCIT_C692 subClassOf NCIT_C1909 @default.
- NCIT_C692 subClassOf NCIT_C270 @default.
- NCIT_C692 subClassOf NCIT_C333 @default.
- NCIT_C692 subClassOf NCIT_C692 @default.
- NCIT_C692 subClassOf NCIT_C78274 @default.
- NCIT_C692 subClassOf NCIT_C93038 @default.