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- NCIT_C70597 IAO_0000115 "A water-soluble prodrug of ceftobiprole, a pyrrolidinone cephalosporin antibiotic, with bactericidal activity. Ceftobiprole binds to and inactivates penicillin-binding proteins (PBPs), enzymes involved in the terminal stages of bacterial cell wall assembly and cell wall reshaping during bacterial growth and division. This agent exhibits a broad spectrum of activity against gram-negative and gram-positive pathogens including methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). Ceftobiprole is refractory to hydrolysis by class A and class C lactamases." @default.
- NCIT_C70597 NCIT_NHC0 "C70597" @default.
- NCIT_C70597 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70597 NCIT_P108 "Ceftobiprole Medocaril" @default.
- NCIT_C70597 NCIT_P207 "C1622308" @default.
- NCIT_C70597 NCIT_P210 "252188-71-9" @default.
- NCIT_C70597 NCIT_P319 "N99027V28J" @default.
- NCIT_C70597 NCIT_P322 "FDA" @default.
- NCIT_C70597 NCIT_P329 "570771" @default.
- NCIT_C70597 NCIT_P330 "570771" @default.
- NCIT_C70597 NCIT_P350 "C26H25N8O11S2.Na" @default.
- NCIT_C70597 NCIT_P366 "Ceftobiprole_Medocaril" @default.
- NCIT_C70597 NCIT_P399 "570771" @default.
- NCIT_C70597 normalizedInformationContent "100" @default.
- NCIT_C70597 referenceCount "1" @default.
- NCIT_C70597 hasExactSynonym "5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2Z)-(5-amino-1,2,4-thiadiazol-3-yl) (hydroxyimino)acetyl)amino)-3-((E)-((3'R)-1'-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2-oxo(1,3'-bipyrrolidin)-3-ylidene)methyl)-8-oxo-, Monosodium Salt, (6R,7R)-" @default.
- NCIT_C70597 hasExactSynonym "BAL5788" @default.
- NCIT_C70597 hasExactSynonym "CEFTOBIPROLE MEDOCARIL" @default.
- NCIT_C70597 hasExactSynonym "Ceftobiprole Medocaril Sodium" @default.
- NCIT_C70597 hasExactSynonym "Ceftobiprole Medocaril" @default.
- NCIT_C70597 hasExactSynonym "JNJ30982081" @default.
- NCIT_C70597 hasExactSynonym "RO 65-5788" @default.
- NCIT_C70597 inSubset NCIT_C176424 @default.
- NCIT_C70597 inSubset NCIT_C63923 @default.
- NCIT_C70597 type Class @default.
- NCIT_C70597 isDefinedBy ncit.owl @default.
- NCIT_C70597 label "Ceftobiprole Medocaril" @default.
- NCIT_C70597 subClassOf NCIT_C1908 @default.
- NCIT_C70597 subClassOf NCIT_C1909 @default.
- NCIT_C70597 subClassOf NCIT_C254 @default.
- NCIT_C70597 subClassOf NCIT_C258 @default.
- NCIT_C70597 subClassOf NCIT_C260 @default.
- NCIT_C70597 subClassOf NCIT_C357 @default.
- NCIT_C70597 subClassOf NCIT_C70597 @default.