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- NCIT_C70618 IAO_0000115 "Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components." @default.
- NCIT_C70618 NCIT_A13 NCIT_C128857 @default.
- NCIT_C70618 NCIT_A13 NCIT_C128859 @default.
- NCIT_C70618 NCIT_A13 NCIT_C128863 @default.
- NCIT_C70618 NCIT_NHC0 "C70618" @default.
- NCIT_C70618 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C70618 NCIT_P107 "Complement Component-4" @default.
- NCIT_C70618 NCIT_P108 "Complement Component-4" @default.
- NCIT_C70618 NCIT_P207 "C0009516" @default.
- NCIT_C70618 NCIT_P322 "CTRP" @default.
- NCIT_C70618 NCIT_P322 "NICHD" @default.
- NCIT_C70618 NCIT_P325 "An early component of the classical and mannose binding lectin (MBL) complement activation pathways. C4 is consumed by proteolysis upon activation of the classical and MBL pathways, but not the alternative pathway. C4 levels are generally low in active immune complex diseases mediated by classical or MBL activation, but not alternative activation, with the canonical example being systemic lupus erythematosus." @default.
- NCIT_C70618 NCIT_P366 "Complement_Component-4" @default.
- NCIT_C70618 NCIT_P98 "Human complement component C4 is polymorphic at two loci, C4A and C4B. 13 alleles of C4A and 22 alleles of C4B have been detected. The C4A alleles carry the Rodgers (Rg) blood group antigens while the C4B alleles carry the Childo (Ch) blood group antigens. (SwissProt)" @default.
- NCIT_C70618 NCIT_R45 NCIT_C14182 @default.
- NCIT_C70618 NCIT_R45 NCIT_C14225 @default.
- NCIT_C70618 NCIT_R45 NCIT_C14234 @default.
- NCIT_C70618 NCIT_R45 NCIT_C14250 @default.
- NCIT_C70618 NCIT_R45 NCIT_C14262 @default.
- NCIT_C70618 NCIT_R45 NCIT_C14282 @default.
- NCIT_C70618 NCIT_R45 NCIT_C25796 @default.
- NCIT_C70618 NCIT_R45 NCIT_C79740 @default.
- NCIT_C70618 NCIT_R52 NCIT_C17021 @default.
- NCIT_C70618 NCIT_R52 NCIT_C20027 @default.
- NCIT_C70618 NCIT_R52 NCIT_C21523 @default.
- NCIT_C70618 NCIT_R52 NCIT_C26548 @default.
- NCIT_C70618 NCIT_R53 NCIT_C17828 @default.
- NCIT_C70618 NCIT_R53 NCIT_C17930 @default.
- NCIT_C70618 NCIT_R53 NCIT_C17937 @default.
- NCIT_C70618 NCIT_R53 NCIT_C18839 @default.
- NCIT_C70618 NCIT_R53 NCIT_C21124 @default.
- NCIT_C70618 NCIT_R53 NCIT_C21519 @default.
- NCIT_C70618 NCIT_R54 NCIT_C16612 @default.
- NCIT_C70618 NCIT_R54 NCIT_C21518 @default.
- NCIT_C70618 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C70618 referenceCount "4" @default.
- NCIT_C70618 hasExactSynonym "C4" @default.
- NCIT_C70618 hasExactSynonym "Complement C4" @default.
- NCIT_C70618 hasExactSynonym "Complement Component-4" @default.
- NCIT_C70618 inSubset NCIT_C116977 @default.
- NCIT_C70618 inSubset NCIT_C118468 @default.
- NCIT_C70618 inSubset NCIT_C142799 @default.
- NCIT_C70618 inSubset NCIT_C142800 @default.
- NCIT_C70618 inSubset NCIT_C90259 @default.
- NCIT_C70618 type Class @default.
- NCIT_C70618 isDefinedBy ncit.owl @default.
- NCIT_C70618 label "Complement Component-4" @default.
- NCIT_C70618 subClassOf B01413f91cc54dc182227a37654735916 @default.
- NCIT_C70618 subClassOf B1f13541b0cf09e8b4f610a13a7f22c6e @default.
- NCIT_C70618 subClassOf B629fd9bbe3bc85738cf9ded8d90aa266 @default.
- NCIT_C70618 subClassOf B83548e637c80796108a359fdef7bea1f @default.
- NCIT_C70618 subClassOf B91cad9ecdc27c775162564785eac426d @default.
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- NCIT_C70618 subClassOf Bbef858b6388311404e81e66cee0b49e3 @default.
- NCIT_C70618 subClassOf Bc65b0519ceeda10025e439e7b36b8a50 @default.
- NCIT_C70618 subClassOf NCIT_C17021 @default.
- NCIT_C70618 subClassOf NCIT_C20130 @default.
- NCIT_C70618 subClassOf NCIT_C26548 @default.
- NCIT_C70618 subClassOf NCIT_C70618 @default.