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- NCIT_C70625 IAO_0000115 "A structural analogue of erastin with potential antineoplastic activity. Erastin analogue PRLX 93936 appears to inhibit mitochondrial outer membrane protein VDACs (voltage-dependent anion channels) 2 and 3, resulting in an oxidative, non-apoptotic cell death. Erastin analogue PRLX 93936 exhibits greater lethality in cell lines harboring mutations in the GTPase protein oncogenes HRAS and KRAS or the serine-threonine protein kinase oncogene BRAF than in non-tumorigenic cell lines. VDACs 2 and 3 are up-regulated in a wide variety of tumor cell lines." @default.
- NCIT_C70625 NCIT_A32 NCIT_C1909 @default.
- NCIT_C70625 NCIT_A7 NCIT_C37294 @default.
- NCIT_C70625 NCIT_A7 NCIT_C37296 @default.
- NCIT_C70625 NCIT_NHC0 "C70625" @default.
- NCIT_C70625 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70625 NCIT_P107 "Erastin Analogue PRLX 93936" @default.
- NCIT_C70625 NCIT_P108 "Erastin Analogue PRLX 93936" @default.
- NCIT_C70625 NCIT_P171 "17568748" @default.
- NCIT_C70625 NCIT_P208 "CL375988" @default.
- NCIT_C70625 NCIT_P322 "CTRP" @default.
- NCIT_C70625 NCIT_P322 "GDC" @default.
- NCIT_C70625 NCIT_P329 "570728" @default.
- NCIT_C70625 NCIT_P330 "570728" @default.
- NCIT_C70625 NCIT_P366 "Erastin_Analogue_PRLX93936" @default.
- NCIT_C70625 NCIT_P375 "Erastin Analogue PRLX 93936" @default.
- NCIT_C70625 NCIT_P399 "570728" @default.
- NCIT_C70625 normalizedInformationContent "100" @default.
- NCIT_C70625 referenceCount "1" @default.
- NCIT_C70625 hasExactSynonym "Erastin Analogue PRLX 93936" @default.
- NCIT_C70625 hasExactSynonym "PRLX 93936" @default.
- NCIT_C70625 inSubset NCIT_C116977 @default.
- NCIT_C70625 inSubset NCIT_C116978 @default.
- NCIT_C70625 inSubset NCIT_C128784 @default.
- NCIT_C70625 inSubset NCIT_C157711 @default.
- NCIT_C70625 inSubset NCIT_C157712 @default.
- NCIT_C70625 inSubset NCIT_C176424 @default.
- NCIT_C70625 inSubset NCIT_C177537 @default.
- NCIT_C70625 type Class @default.
- NCIT_C70625 isDefinedBy ncit.owl @default.
- NCIT_C70625 label "Erastin Analogue PRLX 93936" @default.
- NCIT_C70625 subClassOf NCIT_C129824 @default.
- NCIT_C70625 subClassOf NCIT_C1908 @default.
- NCIT_C70625 subClassOf NCIT_C1909 @default.
- NCIT_C70625 subClassOf NCIT_C2189 @default.
- NCIT_C70625 subClassOf NCIT_C274 @default.
- NCIT_C70625 subClassOf NCIT_C70625 @default.