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- NCIT_C70741 IAO_0000115 "A glycoengineered, humanized IgG1 monoclonal antibody with potential antineoplastic activity. Obinutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells." @default.
- NCIT_C70741 NCIT_A32 NCIT_C1909 @default.
- NCIT_C70741 NCIT_NHC0 "C70741" @default.
- NCIT_C70741 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C70741 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C70741 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70741 NCIT_P107 "Obinutuzumab" @default.
- NCIT_C70741 NCIT_P108 "Obinutuzumab" @default.
- NCIT_C70741 NCIT_P207 "C2742503" @default.
- NCIT_C70741 NCIT_P210 "949142-50-1" @default.
- NCIT_C70741 NCIT_P302 "follicular lymphoma (FL); chronic lymphocytic leukemia" @default.
- NCIT_C70741 NCIT_P319 "O43472U9X8" @default.
- NCIT_C70741 NCIT_P322 "CTRP" @default.
- NCIT_C70741 NCIT_P322 "FDA" @default.
- NCIT_C70741 NCIT_P322 "GDC" @default.
- NCIT_C70741 NCIT_P329 "570643" @default.
- NCIT_C70741 NCIT_P330 "570643" @default.
- NCIT_C70741 NCIT_P366 "Anti-CD20_Monoclonal_Antibody_R7159" @default.
- NCIT_C70741 NCIT_P375 "Obinutuzumab" @default.
- NCIT_C70741 NCIT_P399 "570643" @default.
- NCIT_C70741 NCIT_R124 NCIT_C17710 @default.
- NCIT_C70741 NCIT_R124 NCIT_C17828 @default.
- NCIT_C70741 NCIT_R124 NCIT_C18219 @default.
- NCIT_C70741 NCIT_R124 NCIT_C19986 @default.
- NCIT_C70741 NCIT_R124 NCIT_C40474 @default.
- NCIT_C70741 NCIT_R125 NCIT_C16298 @default.
- NCIT_C70741 NCIT_R125 NCIT_C17709 @default.
- NCIT_C70741 NCIT_R125 NCIT_C17828 @default.
- NCIT_C70741 NCIT_R125 NCIT_C17930 @default.
- NCIT_C70741 NCIT_R125 NCIT_C17937 @default.
- NCIT_C70741 NCIT_R125 NCIT_C18839 @default.
- NCIT_C70741 NCIT_R125 NCIT_C21124 @default.
- NCIT_C70741 NCIT_R72 NCIT_C104083 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12219 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12474 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12476 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12508 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12535 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12542 @default.
- NCIT_C70741 NCIT_R72 NCIT_C12543 @default.
- NCIT_C70741 NCIT_R72 NCIT_C21599 @default.
- NCIT_C70741 NCIT_R72 NCIT_C32725 @default.
- NCIT_C70741 NCIT_R72 NCIT_C33061 @default.
- NCIT_C70741 NCIT_R72 NCIT_C38434 @default.
- NCIT_C70741 NCIT_R72 NCIT_C38439 @default.
- NCIT_C70741 NCIT_R72 NCIT_C39567 @default.
- NCIT_C70741 NCIT_R72 NCIT_C39568 @default.
- NCIT_C70741 normalizedInformationContent "82.536929774922015" @default.
- NCIT_C70741 referenceCount "14" @default.
- NCIT_C70741 hasExactSynonym "Afutuzumab" @default.
- NCIT_C70741 hasExactSynonym "Anti-CD20 Monoclonal Antibody R7159" @default.
- NCIT_C70741 hasExactSynonym "GA-101" @default.
- NCIT_C70741 hasExactSynonym "GA101" @default.
- NCIT_C70741 hasExactSynonym "Gazyva" @default.
- NCIT_C70741 hasExactSynonym "OBINUTUZUMAB" @default.
- NCIT_C70741 hasExactSynonym "Obinutuzumab" @default.
- NCIT_C70741 hasExactSynonym "R7159" @default.
- NCIT_C70741 hasExactSynonym "RO 5072759" @default.
- NCIT_C70741 hasExactSynonym "RO-5072759" @default.
- NCIT_C70741 hasExactSynonym "RO5072759" @default.
- NCIT_C70741 hasExactSynonym "huMAB(CD20)" @default.
- NCIT_C70741 inSubset NCIT_C116977 @default.
- NCIT_C70741 inSubset NCIT_C116978 @default.
- NCIT_C70741 inSubset NCIT_C128784 @default.
- NCIT_C70741 inSubset NCIT_C157711 @default.
- NCIT_C70741 inSubset NCIT_C157712 @default.
- NCIT_C70741 inSubset NCIT_C176424 @default.
- NCIT_C70741 inSubset NCIT_C177537 @default.
- NCIT_C70741 inSubset NCIT_C63923 @default.
- NCIT_C70741 type Class @default.
- NCIT_C70741 isDefinedBy ncit.owl @default.
- NCIT_C70741 label "Obinutuzumab" @default.
- NCIT_C70741 subClassOf B100544e0355ad46b7e3b437480be7c59 @default.
- NCIT_C70741 subClassOf B406e941d39b8e5ae22d8dd6d08c581e6 @default.
- NCIT_C70741 subClassOf B41c49fed4a821d31892f656e69317452 @default.
- NCIT_C70741 subClassOf B65c904c8660a2c3627659726de8b4e40 @default.
- NCIT_C70741 subClassOf B7f83545421d6ccd6dcb6f334a40d1117 @default.
- NCIT_C70741 subClassOf B9ad9a6ae4d7e79500f3c8a673ce9abc7 @default.
- NCIT_C70741 subClassOf Bcc4b14c3f23cfcc19de353f9a05aeda3 @default.
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- NCIT_C70741 subClassOf NCIT_C129821 @default.
- NCIT_C70741 subClassOf NCIT_C129822 @default.
- NCIT_C70741 subClassOf NCIT_C141215 @default.
- NCIT_C70741 subClassOf NCIT_C163758 @default.
- NCIT_C70741 subClassOf NCIT_C164034 @default.
- NCIT_C70741 subClassOf NCIT_C1908 @default.
- NCIT_C70741 subClassOf NCIT_C1909 @default.
- NCIT_C70741 subClassOf NCIT_C20401 @default.
- NCIT_C70741 subClassOf NCIT_C274 @default.
- NCIT_C70741 subClassOf NCIT_C307 @default.
- NCIT_C70741 subClassOf NCIT_C308 @default.
- NCIT_C70741 subClassOf NCIT_C70741 @default.