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- NCIT_C70797 IAO_0000115 "A proprietary antibody-based single-chain polypeptide with B cell-depleting activity. Significantly smaller than a whole antibody, CD20-targeted polypeptide TRU-015 binds specifically to the B cell-specific cell surface antigen CD20 with full immunoglobulin Fv fragment-type target binding activity and full immunoglobulin Fc fragment-type effector function. This agent transiently depletes CD20-bearing B cells by inducing B cell -directed complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) and B cell apoptosis." @default.
- NCIT_C70797 NCIT_NHC0 "C70797" @default.
- NCIT_C70797 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70797 NCIT_P108 "CD20-targeted Polypeptide TRU-015" @default.
- NCIT_C70797 NCIT_P208 "CL375944" @default.
- NCIT_C70797 NCIT_P210 "1169717-01-4" @default.
- NCIT_C70797 NCIT_P319 "T0N62K2M2Y" @default.
- NCIT_C70797 NCIT_P322 "FDA" @default.
- NCIT_C70797 NCIT_P329 "570533" @default.
- NCIT_C70797 NCIT_P330 "570533" @default.
- NCIT_C70797 NCIT_P366 "CD20-targeted_Compound_TRU-015" @default.
- NCIT_C70797 NCIT_P399 "570533" @default.
- NCIT_C70797 NCIT_R146 NCIT_C16725 @default.
- NCIT_C70797 NCIT_R146 NCIT_C17021 @default.
- NCIT_C70797 NCIT_R146 NCIT_C20027 @default.
- NCIT_C70797 NCIT_R146 NCIT_C26548 @default.
- NCIT_C70797 NCIT_R146 NCIT_C38896 @default.
- NCIT_C70797 normalizedInformationContent "100" @default.
- NCIT_C70797 referenceCount "1" @default.
- NCIT_C70797 hasExactSynonym "CD20-targeted Polypeptide TRU-015" @default.
- NCIT_C70797 hasExactSynonym "TRU-015" @default.
- NCIT_C70797 inSubset NCIT_C176424 @default.
- NCIT_C70797 inSubset NCIT_C63923 @default.
- NCIT_C70797 type Class @default.
- NCIT_C70797 isDefinedBy ncit.owl @default.
- NCIT_C70797 label "CD20-targeted Polypeptide TRU-015" @default.
- NCIT_C70797 subClassOf B5a0c197325864a7bdf719ca2a98fad8a @default.
- NCIT_C70797 subClassOf Bfe71a902f3261b69f85134becd7fcd03 @default.
- NCIT_C70797 subClassOf NCIT_C1512 @default.
- NCIT_C70797 subClassOf NCIT_C1908 @default.
- NCIT_C70797 subClassOf NCIT_C1909 @default.
- NCIT_C70797 subClassOf NCIT_C307 @default.
- NCIT_C70797 subClassOf NCIT_C308 @default.
- NCIT_C70797 subClassOf NCIT_C70797 @default.