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- NCIT_C70948 IAO_0000115 "A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner." @default.
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- NCIT_C70948 NCIT_P108 "Polo-like Kinase 1 Inhibitor GSK461364" @default.
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- NCIT_C70948 NCIT_P329 "573587" @default.
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- NCIT_C70948 NCIT_P366 "Polo-like_Kinase_1_Inhibitor_GSK461364" @default.
- NCIT_C70948 NCIT_P375 "Polo-like Kinase 1 Inhibitor GSK461364" @default.
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- NCIT_C70948 hasExactSynonym "GSK461364" @default.
- NCIT_C70948 hasExactSynonym "Polo-like Kinase 1 Inhibitor GSK461364" @default.
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- NCIT_C70948 label "Polo-like Kinase 1 Inhibitor GSK461364" @default.
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