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- NCIT_C70982 IAO_0000115 "An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis." @default.
- NCIT_C70982 NCIT_A32 NCIT_C1909 @default.
- NCIT_C70982 NCIT_A7 NCIT_C17531 @default.
- NCIT_C70982 NCIT_NHC0 "C70982" @default.
- NCIT_C70982 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70982 NCIT_P107 "Linsitinib" @default.
- NCIT_C70982 NCIT_P108 "Linsitinib" @default.
- NCIT_C70982 NCIT_P207 "C2346449" @default.
- NCIT_C70982 NCIT_P210 "867160-71-2" @default.
- NCIT_C70982 NCIT_P319 "15A52GPT8T" @default.
- NCIT_C70982 NCIT_P322 "CTRP" @default.
- NCIT_C70982 NCIT_P322 "FDA" @default.
- NCIT_C70982 NCIT_P322 "GDC" @default.
- NCIT_C70982 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor." @default.
- NCIT_C70982 NCIT_P329 "566191" @default.
- NCIT_C70982 NCIT_P330 "566191" @default.
- NCIT_C70982 NCIT_P350 "C26H23N5O" @default.
- NCIT_C70982 NCIT_P366 "IGF-1R_Inhibitor_OSI-906" @default.
- NCIT_C70982 NCIT_P375 "Linsitinib" @default.
- NCIT_C70982 NCIT_P399 "566191" @default.
- NCIT_C70982 normalizedInformationContent "100" @default.
- NCIT_C70982 referenceCount "1" @default.
- NCIT_C70982 hasExactSynonym "Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-" @default.
- NCIT_C70982 hasExactSynonym "IGF-1R inhibitor OSI-906" @default.
- NCIT_C70982 hasExactSynonym "LINSITINIB" @default.
- NCIT_C70982 hasExactSynonym "Linsitinib" @default.
- NCIT_C70982 hasExactSynonym "OSI-906" @default.
- NCIT_C70982 hasExactSynonym "OSI-906AA" @default.
- NCIT_C70982 hasExactSynonym "cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo(1,5-A)Pyrazin-3-yl)-1-Methylcyclobutanol" @default.
- NCIT_C70982 inSubset NCIT_C116977 @default.
- NCIT_C70982 inSubset NCIT_C116978 @default.
- NCIT_C70982 inSubset NCIT_C128784 @default.
- NCIT_C70982 inSubset NCIT_C157711 @default.
- NCIT_C70982 inSubset NCIT_C157712 @default.
- NCIT_C70982 inSubset NCIT_C176424 @default.
- NCIT_C70982 inSubset NCIT_C177537 @default.
- NCIT_C70982 inSubset NCIT_C63923 @default.
- NCIT_C70982 type Class @default.
- NCIT_C70982 isDefinedBy ncit.owl @default.
- NCIT_C70982 label "Linsitinib" @default.
- NCIT_C70982 subClassOf NCIT_C129824 @default.
- NCIT_C70982 subClassOf NCIT_C129825 @default.
- NCIT_C70982 subClassOf NCIT_C1404 @default.
- NCIT_C70982 subClassOf NCIT_C1908 @default.
- NCIT_C70982 subClassOf NCIT_C1909 @default.
- NCIT_C70982 subClassOf NCIT_C1967 @default.
- NCIT_C70982 subClassOf NCIT_C2189 @default.
- NCIT_C70982 subClassOf NCIT_C274 @default.
- NCIT_C70982 subClassOf NCIT_C471 @default.
- NCIT_C70982 subClassOf NCIT_C70982 @default.