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- NCIT_C70983 IAO_0000115 "An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells." @default.
- NCIT_C70983 NCIT_A32 NCIT_C1909 @default.
- NCIT_C70983 NCIT_A7 NCIT_C30006 @default.
- NCIT_C70983 NCIT_NHC0 "C70983" @default.
- NCIT_C70983 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70983 NCIT_P107 "Aurora Kinase/VEGFR2 Inhibitor CYC116" @default.
- NCIT_C70983 NCIT_P108 "Aurora Kinase/VEGFR2 Inhibitor CYC116" @default.
- NCIT_C70983 NCIT_P207 "C2346878" @default.
- NCIT_C70983 NCIT_P322 "CTRP" @default.
- NCIT_C70983 NCIT_P322 "GDC" @default.
- NCIT_C70983 NCIT_P325 "A substance being studied in the treatment of some types of cancer. It blocks certain enzymes involved in cell division and may kill cancer cells. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of protein kinase inhibitor and a type of antiangiogenesis agent." @default.
- NCIT_C70983 NCIT_P329 "566443" @default.
- NCIT_C70983 NCIT_P330 "566443" @default.
- NCIT_C70983 NCIT_P366 "Aurora_Kinase_VEGFR2_Inhibitor_CYC116" @default.
- NCIT_C70983 NCIT_P375 "Aurora Kinase/VEGFR2 Inhibitor CYC116" @default.
- NCIT_C70983 NCIT_P399 "566443" @default.
- NCIT_C70983 normalizedInformationContent "100" @default.
- NCIT_C70983 referenceCount "1" @default.
- NCIT_C70983 hasExactSynonym "Aurora Kinase/VEGFR2 Inhibitor CYC116" @default.
- NCIT_C70983 hasExactSynonym "CYC116" @default.
- NCIT_C70983 inSubset NCIT_C116977 @default.
- NCIT_C70983 inSubset NCIT_C116978 @default.
- NCIT_C70983 inSubset NCIT_C128784 @default.
- NCIT_C70983 inSubset NCIT_C157711 @default.
- NCIT_C70983 inSubset NCIT_C157712 @default.
- NCIT_C70983 inSubset NCIT_C176424 @default.
- NCIT_C70983 inSubset NCIT_C177537 @default.
- NCIT_C70983 type Class @default.
- NCIT_C70983 isDefinedBy ncit.owl @default.
- NCIT_C70983 label "Aurora Kinase/VEGFR2 Inhibitor CYC116" @default.
- NCIT_C70983 subClassOf NCIT_C129824 @default.
- NCIT_C70983 subClassOf NCIT_C129825 @default.
- NCIT_C70983 subClassOf NCIT_C1404 @default.
- NCIT_C70983 subClassOf NCIT_C1742 @default.
- NCIT_C70983 subClassOf NCIT_C1908 @default.
- NCIT_C70983 subClassOf NCIT_C1909 @default.
- NCIT_C70983 subClassOf NCIT_C2189 @default.
- NCIT_C70983 subClassOf NCIT_C274 @default.
- NCIT_C70983 subClassOf NCIT_C471 @default.
- NCIT_C70983 subClassOf NCIT_C70983 @default.