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- NCIT_C70984 IAO_0000115 "A galectin-binding polysaccharide derived from citrus pectin with potential antineoplastic activity. Apoptosis inducer GCS-100 binds to the carbohydrate-binding domain of the lectin galectin-3, which may result in apoptosis mediated through mitochondria/caspase activation cascades; this agent may overcome tumor growth mediated through anti-apoptotic protein Bcl-2, heat-shock protein 27 (Hsp27), and nuclear factor-kappa B (NF-kB). Galectin-3, a chimeric molecule consisting of both carbohydrate recognition and collagen-like domains, interacts with a variety of carbohydrate and protein ligands to form pentamers with unique crosslinking abilities; this lectin also exhibits anti-apoptotic properties, perhaps, in part, through the regulation of intracellular signaling pathways." @default.
- NCIT_C70984 NCIT_A32 NCIT_C1909 @default.
- NCIT_C70984 NCIT_A7 NCIT_C104859 @default.
- NCIT_C70984 NCIT_NHC0 "C70984" @default.
- NCIT_C70984 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C70984 NCIT_P107 "Apoptosis Inducer GCS-100" @default.
- NCIT_C70984 NCIT_P108 "Apoptosis Inducer GCS-100" @default.
- NCIT_C70984 NCIT_P207 "C1690444" @default.
- NCIT_C70984 NCIT_P319 "3HO3IZ2ILX" @default.
- NCIT_C70984 NCIT_P322 "CTRP" @default.
- NCIT_C70984 NCIT_P322 "FDA" @default.
- NCIT_C70984 NCIT_P322 "GDC" @default.
- NCIT_C70984 NCIT_P329 "567705" @default.
- NCIT_C70984 NCIT_P330 "567705" @default.
- NCIT_C70984 NCIT_P366 "Apoptosis_Inducer_GCS-100" @default.
- NCIT_C70984 NCIT_P375 "Apoptosis Inducer GCS-100" @default.
- NCIT_C70984 NCIT_P399 "567705" @default.
- NCIT_C70984 normalizedInformationContent "100" @default.
- NCIT_C70984 referenceCount "1" @default.
- NCIT_C70984 hasExactSynonym "Apoptosis Inducer GCS-100" @default.
- NCIT_C70984 hasExactSynonym "GCS-100" @default.
- NCIT_C70984 inSubset NCIT_C116977 @default.
- NCIT_C70984 inSubset NCIT_C116978 @default.
- NCIT_C70984 inSubset NCIT_C128784 @default.
- NCIT_C70984 inSubset NCIT_C157711 @default.
- NCIT_C70984 inSubset NCIT_C157712 @default.
- NCIT_C70984 inSubset NCIT_C176424 @default.
- NCIT_C70984 inSubset NCIT_C177537 @default.
- NCIT_C70984 inSubset NCIT_C63923 @default.
- NCIT_C70984 type Class @default.
- NCIT_C70984 isDefinedBy ncit.owl @default.
- NCIT_C70984 label "Apoptosis Inducer GCS-100" @default.
- NCIT_C70984 subClassOf NCIT_C129839 @default.
- NCIT_C70984 subClassOf NCIT_C1908 @default.
- NCIT_C70984 subClassOf NCIT_C1909 @default.
- NCIT_C70984 subClassOf NCIT_C274 @default.
- NCIT_C70984 subClassOf NCIT_C70984 @default.