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- NCIT_C71009 IAO_0000115 "An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Coltuximab ravtansine targets the cell surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen binding and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CD19-expressing tumor cells." @default.
- NCIT_C71009 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71009 NCIT_A7 NCIT_C38894 @default.
- NCIT_C71009 NCIT_NHC0 "C71009" @default.
- NCIT_C71009 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C71009 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71009 NCIT_P107 "Coltuximab Ravtansine" @default.
- NCIT_C71009 NCIT_P108 "Coltuximab Ravtansine" @default.
- NCIT_C71009 NCIT_P207 "C2346794" @default.
- NCIT_C71009 NCIT_P210 "1269764-99-9" @default.
- NCIT_C71009 NCIT_P319 "MRS84YT9L2" @default.
- NCIT_C71009 NCIT_P322 "CTRP" @default.
- NCIT_C71009 NCIT_P322 "FDA" @default.
- NCIT_C71009 NCIT_P322 "GDC" @default.
- NCIT_C71009 NCIT_P329 "574048" @default.
- NCIT_C71009 NCIT_P330 "574048" @default.
- NCIT_C71009 NCIT_P366 "Anti-CD19-DM4_Conjugate" @default.
- NCIT_C71009 NCIT_P375 "Anti-CD19-DM4 Immunoconjugate SAR3419" @default.
- NCIT_C71009 NCIT_P375 "Coltuximab Ravtansine" @default.
- NCIT_C71009 NCIT_P399 "574048" @default.
- NCIT_C71009 normalizedInformationContent "100" @default.
- NCIT_C71009 referenceCount "1" @default.
- NCIT_C71009 hasExactSynonym "Anti-CD19-DM4 Immunoconjugate SAR3419" @default.
- NCIT_C71009 hasExactSynonym "COLTUXIMAB RAVTANSINE" @default.
- NCIT_C71009 hasExactSynonym "Coltuximab Ravtansine" @default.
- NCIT_C71009 hasExactSynonym "SAR3419" @default.
- NCIT_C71009 inSubset NCIT_C116977 @default.
- NCIT_C71009 inSubset NCIT_C116978 @default.
- NCIT_C71009 inSubset NCIT_C128784 @default.
- NCIT_C71009 inSubset NCIT_C157711 @default.
- NCIT_C71009 inSubset NCIT_C157712 @default.
- NCIT_C71009 inSubset NCIT_C176424 @default.
- NCIT_C71009 inSubset NCIT_C177537 @default.
- NCIT_C71009 inSubset NCIT_C63923 @default.
- NCIT_C71009 type Class @default.
- NCIT_C71009 isDefinedBy ncit.owl @default.
- NCIT_C71009 label "Coltuximab Ravtansine" @default.
- NCIT_C71009 subClassOf NCIT_C129821 @default.
- NCIT_C71009 subClassOf NCIT_C129823 @default.
- NCIT_C71009 subClassOf NCIT_C1512 @default.
- NCIT_C71009 subClassOf NCIT_C163758 @default.
- NCIT_C71009 subClassOf NCIT_C1908 @default.
- NCIT_C71009 subClassOf NCIT_C1909 @default.
- NCIT_C71009 subClassOf NCIT_C198634 @default.
- NCIT_C71009 subClassOf NCIT_C198859 @default.
- NCIT_C71009 subClassOf NCIT_C274 @default.
- NCIT_C71009 subClassOf NCIT_C307 @default.
- NCIT_C71009 subClassOf NCIT_C308 @default.
- NCIT_C71009 subClassOf NCIT_C71009 @default.