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- NCIT_C71015 IAO_0000115 "A fully human monoclonal agonist antibody directed against the extracellular domain of human TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptor 2 (TR-2) with potential antineoplastic activity. Conatumumab mimics the activity of native TRAIL, binding to and activating TR-2, thereby activating caspase cascades and inducing tumor cell apoptosis. TR-2 is expressed by a variety of solid tumors and cancers of hematopoietic origin." @default.
- NCIT_C71015 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71015 NCIT_A7 NCIT_C18178 @default.
- NCIT_C71015 NCIT_NHC0 "C71015" @default.
- NCIT_C71015 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C71015 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71015 NCIT_P107 "Conatumumab" @default.
- NCIT_C71015 NCIT_P108 "Conatumumab" @default.
- NCIT_C71015 NCIT_P207 "C2346822" @default.
- NCIT_C71015 NCIT_P210 "896731-82-1" @default.
- NCIT_C71015 NCIT_P319 "1P48L61KM0" @default.
- NCIT_C71015 NCIT_P322 "CTRP" @default.
- NCIT_C71015 NCIT_P322 "FDA" @default.
- NCIT_C71015 NCIT_P322 "GDC" @default.
- NCIT_C71015 NCIT_P329 "573083" @default.
- NCIT_C71015 NCIT_P330 "573083" @default.
- NCIT_C71015 NCIT_P366 "Anti-TRAIL_Receptor_2_Monoclonal_Antibody_AMG_655" @default.
- NCIT_C71015 NCIT_P375 "Conatumumab" @default.
- NCIT_C71015 NCIT_P399 "573083" @default.
- NCIT_C71015 NCIT_R124 NCIT_C17710 @default.
- NCIT_C71015 NCIT_R124 NCIT_C17828 @default.
- NCIT_C71015 NCIT_R124 NCIT_C18219 @default.
- NCIT_C71015 NCIT_R124 NCIT_C19986 @default.
- NCIT_C71015 NCIT_R124 NCIT_C40474 @default.
- NCIT_C71015 normalizedInformationContent "100" @default.
- NCIT_C71015 referenceCount "1" @default.
- NCIT_C71015 hasExactSynonym "AMG 655" @default.
- NCIT_C71015 hasExactSynonym "Anti-TRAIL Receptor 2 Monoclonal Antibody AMG 655" @default.
- NCIT_C71015 hasExactSynonym "CONATUMUMAB" @default.
- NCIT_C71015 hasExactSynonym "Conatumumab" @default.
- NCIT_C71015 hasExactSynonym "Immunoglobulin G1, Anti-(Human Tumor Necrosis Factor Receptor Superfamily Member 10b (Death Receptor 5, Trail-R2, CD262 Antigen))" @default.
- NCIT_C71015 hasExactSynonym "Monoclonal XG1-048 (Arg(Sup 219),Glu(Sup 361),Met(Sup 363))Gamma-1 Heavy Chain (225-215')-Disulphide With Kappa Light Chain (231-231'':234-234'')-Bisdisulphide Dimer" @default.
- NCIT_C71015 inSubset NCIT_C116977 @default.
- NCIT_C71015 inSubset NCIT_C116978 @default.
- NCIT_C71015 inSubset NCIT_C128784 @default.
- NCIT_C71015 inSubset NCIT_C157711 @default.
- NCIT_C71015 inSubset NCIT_C157712 @default.
- NCIT_C71015 inSubset NCIT_C176424 @default.
- NCIT_C71015 inSubset NCIT_C177537 @default.
- NCIT_C71015 inSubset NCIT_C63923 @default.
- NCIT_C71015 type Class @default.
- NCIT_C71015 isDefinedBy ncit.owl @default.
- NCIT_C71015 label "Conatumumab" @default.
- NCIT_C71015 subClassOf NCIT_C129821 @default.
- NCIT_C71015 subClassOf NCIT_C129822 @default.
- NCIT_C71015 subClassOf NCIT_C1908 @default.
- NCIT_C71015 subClassOf NCIT_C1909 @default.
- NCIT_C71015 subClassOf NCIT_C20401 @default.
- NCIT_C71015 subClassOf NCIT_C274 @default.
- NCIT_C71015 subClassOf NCIT_C307 @default.
- NCIT_C71015 subClassOf NCIT_C308 @default.
- NCIT_C71015 subClassOf NCIT_C71015 @default.