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- NCIT_C71149 IAO_0000115 "An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin." @default.
- NCIT_C71149 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71149 NCIT_A7 NCIT_C18434 @default.
- NCIT_C71149 NCIT_A7 NCIT_C449 @default.
- NCIT_C71149 NCIT_NHC0 "C71149" @default.
- NCIT_C71149 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71149 NCIT_P107 "PVA Microporous Hydrospheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 NCIT_P108 "PVA Microporous Hydrospheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 NCIT_P208 "CL376223" @default.
- NCIT_C71149 NCIT_P322 "CTRP" @default.
- NCIT_C71149 NCIT_P322 "GDC" @default.
- NCIT_C71149 NCIT_P329 "574045" @default.
- NCIT_C71149 NCIT_P330 "574045" @default.
- NCIT_C71149 NCIT_P366 "PVA_Microporous_Hydrospheres_Doxorubicin_Hydrochloride" @default.
- NCIT_C71149 NCIT_P375 "PVA Microporous Hydrospheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 NCIT_P399 "574045" @default.
- NCIT_C71149 normalizedInformationContent "100" @default.
- NCIT_C71149 referenceCount "1" @default.
- NCIT_C71149 hasExactSynonym "HepaSphere Microspheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 hasExactSynonym "PVA Microporous Hydrospheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 hasExactSynonym "QuadraSphere Microspheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 inSubset NCIT_C116977 @default.
- NCIT_C71149 inSubset NCIT_C116978 @default.
- NCIT_C71149 inSubset NCIT_C128784 @default.
- NCIT_C71149 inSubset NCIT_C157711 @default.
- NCIT_C71149 inSubset NCIT_C157712 @default.
- NCIT_C71149 inSubset NCIT_C176424 @default.
- NCIT_C71149 inSubset NCIT_C177537 @default.
- NCIT_C71149 type Class @default.
- NCIT_C71149 isDefinedBy ncit.owl @default.
- NCIT_C71149 label "PVA Microporous Hydrospheres/Doxorubicin Hydrochloride" @default.
- NCIT_C71149 subClassOf NCIT_C129824 @default.
- NCIT_C71149 subClassOf NCIT_C129825 @default.
- NCIT_C71149 subClassOf NCIT_C1594 @default.
- NCIT_C71149 subClassOf NCIT_C1748 @default.
- NCIT_C71149 subClassOf NCIT_C186664 @default.
- NCIT_C71149 subClassOf NCIT_C1908 @default.
- NCIT_C71149 subClassOf NCIT_C1909 @default.
- NCIT_C71149 subClassOf NCIT_C1968 @default.
- NCIT_C71149 subClassOf NCIT_C2115 @default.
- NCIT_C71149 subClassOf NCIT_C2161 @default.
- NCIT_C71149 subClassOf NCIT_C2189 @default.
- NCIT_C71149 subClassOf NCIT_C259 @default.
- NCIT_C71149 subClassOf NCIT_C274 @default.
- NCIT_C71149 subClassOf NCIT_C2842 @default.
- NCIT_C71149 subClassOf NCIT_C471 @default.
- NCIT_C71149 subClassOf NCIT_C67502 @default.
- NCIT_C71149 subClassOf NCIT_C71149 @default.