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- NCIT_C71154 IAO_0000115 "A formulation of the mustard plant Brassica juncea grown in a medium that has been enriched with the trace element selenium with potential chemopreventive and chemopotentiating activities. Brassica juncea hyperaccumulates trace elements in soil. Selenium amino acid species found in selenized Brassica juncea include methylselenomethionine (MeSeMet) and methylselenocysteine (MeSeCys); both may be incorporated into selenoproteins in vivo. Selenium functions as a cofactor for antioxidant enzymes such as glutathione peroxidases and thioredoxin reductase, which protect cells from the free radical damage. In addition, in vitro MeSeCys has been shown to potentiate the antitumor effects of the irinotecan metabolite SN-38, by inducing phosphorylation of checkpoint kinase 2 (chk2) at threonine 68, which results in poly(ADP-ribose) polymerase cleavage, caspase 3 activation, and DNA fragmentation." @default.
- NCIT_C71154 NCIT_NHC0 "C71154" @default.
- NCIT_C71154 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71154 NCIT_P107 "High-Selenium Brassica juncea" @default.
- NCIT_C71154 NCIT_P108 "High-Selenium Brassica juncea" @default.
- NCIT_C71154 NCIT_P208 "CL377692" @default.
- NCIT_C71154 NCIT_P322 "CTRP" @default.
- NCIT_C71154 NCIT_P325 "Brassica juncea that has been grown in high levels of selenium. Brassica juncea is a plant of the cabbage family that has been used in some cultures to treat certain medical problems, including arthritis, colds, stomach disorders, and tumors. The plant stores minerals, including selenium which may stop tumor cells from growing. High-selenium Brassica juncea is being studied in the treatment of cancer. Brassica juncea is also known as Indian mustard." @default.
- NCIT_C71154 NCIT_P329 "573427" @default.
- NCIT_C71154 NCIT_P330 "573427" @default.
- NCIT_C71154 NCIT_P366 "High-Selenium_Brassica_Juncea" @default.
- NCIT_C71154 NCIT_P399 "573427" @default.
- NCIT_C71154 normalizedInformationContent "100" @default.
- NCIT_C71154 referenceCount "1" @default.
- NCIT_C71154 hasExactSynonym "BJ-Se" @default.
- NCIT_C71154 hasExactSynonym "High-Selenium Brassica juncea" @default.
- NCIT_C71154 hasExactSynonym "high-selenium Brassica juncea" @default.
- NCIT_C71154 inSubset NCIT_C116977 @default.
- NCIT_C71154 inSubset NCIT_C116978 @default.
- NCIT_C71154 inSubset NCIT_C128784 @default.
- NCIT_C71154 inSubset NCIT_C176424 @default.
- NCIT_C71154 type Class @default.
- NCIT_C71154 isDefinedBy ncit.owl @default.
- NCIT_C71154 label "High-Selenium Brassica juncea" @default.
- NCIT_C71154 subClassOf NCIT_C1505 @default.
- NCIT_C71154 subClassOf NCIT_C1908 @default.
- NCIT_C71154 subClassOf NCIT_C71154 @default.