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- NCIT_C71156 IAO_0000115 "The magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties." @default.
- NCIT_C71156 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71156 NCIT_A6 NCIT_C29536 @default.
- NCIT_C71156 NCIT_NHC0 "C71156" @default.
- NCIT_C71156 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71156 NCIT_P108 "Magnesium Valproate" @default.
- NCIT_C71156 NCIT_P207 "C0524735" @default.
- NCIT_C71156 NCIT_P210 "62959-43-7" @default.
- NCIT_C71156 NCIT_P319 "Q400352CM2" @default.
- NCIT_C71156 NCIT_P322 "FDA" @default.
- NCIT_C71156 NCIT_P322 "GDC" @default.
- NCIT_C71156 NCIT_P329 "573418" @default.
- NCIT_C71156 NCIT_P330 "573418" @default.
- NCIT_C71156 NCIT_P350 "2C8H15O2.Mg" @default.
- NCIT_C71156 NCIT_P366 "Magnesium_Valproate" @default.
- NCIT_C71156 NCIT_P375 "Magnesium Valproate" @default.
- NCIT_C71156 NCIT_P399 "573418" @default.
- NCIT_C71156 normalizedInformationContent "100" @default.
- NCIT_C71156 referenceCount "1" @default.
- NCIT_C71156 hasExactSynonym "Magnesium Dipropylacetate" @default.
- NCIT_C71156 hasExactSynonym "Magnesium Valproate" @default.
- NCIT_C71156 hasExactSynonym "Pentanoic acid, 2-propyl-, Magnesium Salt" @default.
- NCIT_C71156 hasExactSynonym "VALPROATE MAGNESIUM" @default.
- NCIT_C71156 hasExactSynonym "Valproate Magnesium" @default.
- NCIT_C71156 inSubset NCIT_C128784 @default.
- NCIT_C71156 inSubset NCIT_C157711 @default.
- NCIT_C71156 inSubset NCIT_C157712 @default.
- NCIT_C71156 inSubset NCIT_C176424 @default.
- NCIT_C71156 inSubset NCIT_C177537 @default.
- NCIT_C71156 inSubset NCIT_C63923 @default.
- NCIT_C71156 type Class @default.
- NCIT_C71156 isDefinedBy ncit.owl @default.
- NCIT_C71156 label "Magnesium Valproate" @default.
- NCIT_C71156 subClassOf NCIT_C163758 @default.
- NCIT_C71156 subClassOf NCIT_C1908 @default.
- NCIT_C71156 subClassOf NCIT_C1909 @default.
- NCIT_C71156 subClassOf NCIT_C1946 @default.
- NCIT_C71156 subClassOf NCIT_C264 @default.
- NCIT_C71156 subClassOf NCIT_C274 @default.
- NCIT_C71156 subClassOf NCIT_C471 @default.
- NCIT_C71156 subClassOf NCIT_C71156 @default.
- NCIT_C71156 subClassOf NCIT_C78272 @default.