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- NCIT_C71355 IAO_0000115 "The sodium salt form of rigosertib, a synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic activity. Upon administration, rigosertib targets and binds to Ras-binding domain (RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol 3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and inhibits proliferation in a variety of susceptible tumor cells." @default.
- NCIT_C71355 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71355 NCIT_A7 NCIT_C30006 @default.
- NCIT_C71355 NCIT_NHC0 "C71355" @default.
- NCIT_C71355 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71355 NCIT_P107 "Rigosertib Sodium" @default.
- NCIT_C71355 NCIT_P108 "Rigosertib Sodium" @default.
- NCIT_C71355 NCIT_P207 "C3467794" @default.
- NCIT_C71355 NCIT_P210 "592542-60-4" @default.
- NCIT_C71355 NCIT_P319 "406FL5G00V" @default.
- NCIT_C71355 NCIT_P322 "CTRP" @default.
- NCIT_C71355 NCIT_P322 "FDA" @default.
- NCIT_C71355 NCIT_P322 "GDC" @default.
- NCIT_C71355 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks certain proteins that are needed for cell growth and may kill cancer cells. ON 01910.Na is a type of protein kinase inhibitor and a type of benzyl styryl sulfone analog." @default.
- NCIT_C71355 NCIT_P329 "573371" @default.
- NCIT_C71355 NCIT_P330 "573371" @default.
- NCIT_C71355 NCIT_P350 "C21H24NO8S.Na" @default.
- NCIT_C71355 NCIT_P366 "Polo-like_kinase_1_Inhibitor_ON_01910_Na" @default.
- NCIT_C71355 NCIT_P375 "Rigosertib Sodium" @default.
- NCIT_C71355 NCIT_P399 "573371" @default.
- NCIT_C71355 NCIT_R125 NCIT_C17133 @default.
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- NCIT_C71355 NCIT_R146 NCIT_C26548 @default.
- NCIT_C71355 normalizedInformationContent "100" @default.
- NCIT_C71355 referenceCount "1" @default.
- NCIT_C71355 hasExactSynonym "ON 01910.Na" @default.
- NCIT_C71355 hasExactSynonym "Polo-like kinase 1 Inhibitor ON 01910.Na" @default.
- NCIT_C71355 hasExactSynonym "RIGOSERTIB SODIUM" @default.
- NCIT_C71355 hasExactSynonym "Rigosertib Sodium" @default.
- NCIT_C71355 inSubset NCIT_C116977 @default.
- NCIT_C71355 inSubset NCIT_C116978 @default.
- NCIT_C71355 inSubset NCIT_C128784 @default.
- NCIT_C71355 inSubset NCIT_C157711 @default.
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- NCIT_C71355 inSubset NCIT_C176424 @default.
- NCIT_C71355 inSubset NCIT_C177537 @default.
- NCIT_C71355 inSubset NCIT_C63923 @default.
- NCIT_C71355 type Class @default.
- NCIT_C71355 isDefinedBy ncit.owl @default.
- NCIT_C71355 label "Rigosertib Sodium" @default.
- NCIT_C71355 subClassOf B0ea84ed1201b585abf91b8e8412312c0 @default.
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- NCIT_C71355 subClassOf NCIT_C1908 @default.
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- NCIT_C71355 subClassOf NCIT_C471 @default.
- NCIT_C71355 subClassOf NCIT_C71355 @default.