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- NCIT_C71524 IAO_0000115 "A folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and stabilizes microtubules against depolymerization, resulting in the inhibition of mitosis and cellular proliferation." @default.
- NCIT_C71524 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71524 NCIT_A7 NCIT_C39284 @default.
- NCIT_C71524 NCIT_NHC0 "C71524" @default.
- NCIT_C71524 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71524 NCIT_P107 "Folate Receptor Targeted Epothilone BMS753493" @default.
- NCIT_C71524 NCIT_P108 "Folate Receptor Targeted Epothilone BMS753493" @default.
- NCIT_C71524 NCIT_P208 "CL376231" @default.
- NCIT_C71524 NCIT_P322 "CTRP" @default.
- NCIT_C71524 NCIT_P322 "GDC" @default.
- NCIT_C71524 NCIT_P329 "575735" @default.
- NCIT_C71524 NCIT_P330 "575735" @default.
- NCIT_C71524 NCIT_P366 "Folate_Receptor-Targeted_Epothilone_BMS753493" @default.
- NCIT_C71524 NCIT_P375 "Folate Receptor Targeted Epothilone BMS753493" @default.
- NCIT_C71524 NCIT_P399 "575735" @default.
- NCIT_C71524 NCIT_R66 NCIT_C17828 @default.
- NCIT_C71524 NCIT_R66 NCIT_C19555 @default.
- NCIT_C71524 NCIT_R66 NCIT_C20480 @default.
- NCIT_C71524 NCIT_R66 NCIT_C40795 @default.
- NCIT_C71524 NCIT_R66 NCIT_C40798 @default.
- NCIT_C71524 NCIT_R66 NCIT_C41588 @default.
- NCIT_C71524 normalizedInformationContent "100" @default.
- NCIT_C71524 referenceCount "1" @default.
- NCIT_C71524 hasExactSynonym "Folate Receptor Targeted Epothilone BMS753493" @default.
- NCIT_C71524 inSubset NCIT_C116977 @default.
- NCIT_C71524 inSubset NCIT_C116978 @default.
- NCIT_C71524 inSubset NCIT_C128784 @default.
- NCIT_C71524 inSubset NCIT_C157711 @default.
- NCIT_C71524 inSubset NCIT_C157712 @default.
- NCIT_C71524 inSubset NCIT_C176424 @default.
- NCIT_C71524 inSubset NCIT_C177537 @default.
- NCIT_C71524 type Class @default.
- NCIT_C71524 isDefinedBy ncit.owl @default.
- NCIT_C71524 label "Folate Receptor Targeted Epothilone BMS753493" @default.
- NCIT_C71524 subClassOf NCIT_C163758 @default.
- NCIT_C71524 subClassOf NCIT_C1908 @default.
- NCIT_C71524 subClassOf NCIT_C1909 @default.
- NCIT_C71524 subClassOf NCIT_C1913 @default.
- NCIT_C71524 subClassOf NCIT_C1922 @default.
- NCIT_C71524 subClassOf NCIT_C200114 @default.
- NCIT_C71524 subClassOf NCIT_C200714 @default.
- NCIT_C71524 subClassOf NCIT_C274 @default.
- NCIT_C71524 subClassOf NCIT_C606 @default.
- NCIT_C71524 subClassOf NCIT_C67445 @default.
- NCIT_C71524 subClassOf NCIT_C71524 @default.
- NCIT_C71524 subClassOf NCIT_C718 @default.
- NCIT_C71524 subClassOf NCIT_C94712 @default.