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- NCIT_C71527 IAO_0000115 "A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Anti-IGF-1R fully human monoclonal antibody SCH 717454 binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; downregulation of this survival pathway may result in the induction of apoptosis and decreased cellular proliferation. The activation of IGF-1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis." @default.
- NCIT_C71527 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71527 NCIT_A7 NCIT_C17531 @default.
- NCIT_C71527 NCIT_NHC0 "C71527" @default.
- NCIT_C71527 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C71527 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C71527 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71527 NCIT_P107 "Robatumumab" @default.
- NCIT_C71527 NCIT_P108 "Robatumumab" @default.
- NCIT_C71527 NCIT_P207 "C3467798" @default.
- NCIT_C71527 NCIT_P210 "934235-44-6" @default.
- NCIT_C71527 NCIT_P319 "V983921H3B" @default.
- NCIT_C71527 NCIT_P322 "CTRP" @default.
- NCIT_C71527 NCIT_P322 "FDA" @default.
- NCIT_C71527 NCIT_P322 "GDC" @default.
- NCIT_C71527 NCIT_P329 "577364" @default.
- NCIT_C71527 NCIT_P330 "577364" @default.
- NCIT_C71527 NCIT_P366 "Anti-IGF-1R_Recombinant_Monoclonal_Antibody_SCH_717454" @default.
- NCIT_C71527 NCIT_P375 "Robatumumab" @default.
- NCIT_C71527 NCIT_P399 "577364" @default.
- NCIT_C71527 NCIT_R124 NCIT_C17710 @default.
- NCIT_C71527 NCIT_R124 NCIT_C17828 @default.
- NCIT_C71527 NCIT_R124 NCIT_C18219 @default.
- NCIT_C71527 NCIT_R124 NCIT_C19986 @default.
- NCIT_C71527 NCIT_R124 NCIT_C40474 @default.
- NCIT_C71527 normalizedInformationContent "100" @default.
- NCIT_C71527 referenceCount "1" @default.
- NCIT_C71527 hasExactSynonym "Anti-IGF-1R Recombinant Monoclonal Antibody SCH 717454" @default.
- NCIT_C71527 hasExactSynonym "Immunoglobulin G1, Anti-(Human Insulin-Like Growth Factor I Receptor) (Human Monoclonal SCH 717454 Heavy Chain), Disulfide with Human Monoclonal SCH 717454 Light Chain, Dimer" @default.
- NCIT_C71527 hasExactSynonym "ROBATUMUMAB" @default.
- NCIT_C71527 hasExactSynonym "Robatumumab" @default.
- NCIT_C71527 hasExactSynonym "Sch717454" @default.
- NCIT_C71527 inSubset NCIT_C116977 @default.
- NCIT_C71527 inSubset NCIT_C116978 @default.
- NCIT_C71527 inSubset NCIT_C128784 @default.
- NCIT_C71527 inSubset NCIT_C157711 @default.
- NCIT_C71527 inSubset NCIT_C157712 @default.
- NCIT_C71527 inSubset NCIT_C176424 @default.
- NCIT_C71527 inSubset NCIT_C177537 @default.
- NCIT_C71527 inSubset NCIT_C63923 @default.
- NCIT_C71527 type Class @default.
- NCIT_C71527 isDefinedBy ncit.owl @default.
- NCIT_C71527 label "Robatumumab" @default.
- NCIT_C71527 subClassOf NCIT_C129821 @default.
- NCIT_C71527 subClassOf NCIT_C129822 @default.
- NCIT_C71527 subClassOf NCIT_C1742 @default.
- NCIT_C71527 subClassOf NCIT_C182012 @default.
- NCIT_C71527 subClassOf NCIT_C1908 @default.
- NCIT_C71527 subClassOf NCIT_C1909 @default.
- NCIT_C71527 subClassOf NCIT_C20401 @default.
- NCIT_C71527 subClassOf NCIT_C274 @default.
- NCIT_C71527 subClassOf NCIT_C307 @default.
- NCIT_C71527 subClassOf NCIT_C308 @default.
- NCIT_C71527 subClassOf NCIT_C71527 @default.